Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 445-760-8 | CAS number: 122886-55-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 December 2002-10 January 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: water treatment plant of Evreux, France, containing effluent from predominantly domestic origin. The inoculum was sampled on 05/12/2002
- Method of cultivation: air was bubbled through the inoculum until use. The temperature was 22 +/- 2 degrees C. The reconstituted water (OECD and EEC recommended) was prepared using deionised water which contained no more than 5% OC.
- Storage conditions: at 22 +/- 2 deg C, in mineral medium under continous aeration
- Storage length: 7 days
- Preparation of inoculum for exposure: the inoculum was prepared by initially decanting and sieving the the sewage sludge. After centrifugation for 5 min, the supernatant was discarded and the pellet was redispersed in the mineral medium.
- Concentration of sludge: 15 mg/L suspended solids (dw) in 3L suspension - Duration of test (contact time):
- 29 d
- Initial conc.:
- 13.3 mg/L
- Based on:
- test mat.
- Initial conc.:
- 10 mg/L
- Based on:
- other: Total Organic Carbon
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: mineral medium according to OECD 301B
- Test temperature: 20 - 23 deg C
- pH: 7.46 - 7.75
- pH adjusted: no
- Aeration of dilution water: aeration at the rate of 30 - 100 ml/min
- Suspended solids concentration: 15 mg/L dry weight. In the control flask 2 the quantity of inoculumadded (by an error) was higher 30 mg/L
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: 3L flasks, dark glass
- Number of culture flasks/concentration: 2
- Measuring equipment: titration equipment. Each time CO2 was analyzed, 100 ml of Ba(OH)2 solution was titrated with 0.05 M HCl.
- Other: the test flask were aerated with CO2-scrubbed air overnight to purge the system of CO2 and then attached in parallel to a series of 3 wash bottles filled 100 ml of 0.0125 Ba(OH)2 to trap any CO2 released from the test vessels. The test and reference (sodium acetate) item were added, where appropriate, to the flasks to give a test and reference item concentrations of 10 mg TOC per liter (39.8 mg of KY-EU and 102.4 mg of sodium acetate). When all the substances have been added, the volume of the suspensions was made up to 3 L.
SAMPLING
- Sampling frequency: measurements of CO2 were made at the following times: days 1, 4, 6, 8, 11, 14, 18, 22, 25 and 29
- Sampling method: For each measurement, the first wash bottle nearest to the test flask was disconnected and titrated with 0.05 M HCl, using phenolphthalein as an indicator. The remaining CO2 absorber bottles were connected absorber bottles to the test flasks so that the second wash wash bottle replaced the first one and an extra bottle containing fresh Ba(OH)2 was added to the far end of the series. On the 28th day, 1 ml of concentrated HCl was added to each test flask to stop the biodegradation and test flasks were aerated overnight to drive off the remaining CO2. A final CO2 analysis of all wash bottles was made on the 29th day.
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Abiotic sterile control: no
- Toxicity control: no
- Other: reference item, sodium acetate at 10 mg/L TOC - Reference substance:
- other: sodium acetate at 10 mg/L TOC
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 32.4
- St. dev.:
- 2.8
- Sampling time:
- 28 d
- Details on results:
- The 10 days window started on day 18 and the average %Degr was 12.86 on day 18.
Validity criteria:
- The CO2 evolution in the blank control bottles at the end of the test was 35.2 mg CO2/L, which is < 70 mg CO2/L
- The difference in biodegradation of test item replicates was <20% at the end of the 10d-window
- The reference substance biodegraded > 60% in 14 days - Results with reference substance:
- Biodegradation in the reference test was 71% after 14 days and 98.6% after 28 days.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: 32.4% biodegradation observed after 28 days
- Conclusions:
- Under the conditions of OECD 301B, KY-EU is not readily biodegradable.
- Executive summary:
The ready biodegradability of KY-EU was investigated in a OECD 301B study, carried out according to GLP.
32.4% biodegradation was observed after 28 days. It was concluded that under the conditions of OECD 301B, KY-EU is not readily biodegradable.
The study is considered reliable without restrictions.
Reference
Description of key information
32.4% biodegradation was observed after 28 days. It was concluded that under the conditions of OECD 301B, KY-EU is not readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
The ready biodegradability of KY-EU was investigated in a OECD 301B study, carried out according to GLP.
32.4% biodegradation was observed after 28 days. It was concluded that under the conditions of OECD 301B, KY-EU is not readily biodegradable.
The study is considered reliable without restrictions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.