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EC number: 246-467-6 | CAS number: 24801-88-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data available
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- (4 animals per dose group (at least 5 recommended), 2 doses (at least 3 recommended), immobilisation not recommended, occlusive application (semi-occlusive recommended), insufficient details to further judge compliance with test guideline)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Triethoxy(3-isocyanatopropyl)silane
- EC Number:
- 246-467-6
- EC Name:
- Triethoxy(3-isocyanatopropyl)silane
- Cas Number:
- 24801-88-5
- Molecular formula:
- C10H21NO4Si
- IUPAC Name:
- triethoxy(3-isocyanatopropyl)silane
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data available
- Age at study initiation: 3 to 5 months
- Weight at study initiation: no data available
- Fasting period before study: no data available
- Housing: no data available
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data available
- Humidity (%): no data available
- Air changes (per hr): no data available
- Photoperiod (hrs dark / hrs light): no data available
IN-LIFE DATES: no data available
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: no data available
- % coverage: no data available
- Type of wrap if used: impervious sheeting
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data available
- Time after start of exposure: no data available
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1 or 2 ml/kg bw [980 or 1970 mg/kg bw]
- Constant volume or concentration used: no data available - Duration of exposure:
- 24 Hours
- Doses:
- 1 or 2 ml/kg bw [980 or 1970 mg/kg bw]
- No. of animals per sex per dose:
- 4 males
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data available
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, skin irritation - Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1.26 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 0.772 - < 2.06
- Remarks on result:
- other: Density 1.0007 g/ml; 1.26 ml/kg bw is equivalent to 1261 mg/kg bw; 4/4 deaths at 2 ml/kg bw, 1/4 deaths at 1 ml/kg bw
- Mortality:
- 1/4 animals given 1 mlkg died (on day 2)
4/4 animals given 2 ml/kg died (on day 1) - Clinical signs:
- other: No clinical signs were reported for animals given 1.0 ml/kg bw In animals given 2 ml/kg bw, rapid breathing and irritability were noted within the first few hours of treatment
- Gross pathology:
- Congestion of the lungs
Spleens, livers and kidneys pale
Livers and kidneys mottled - Other findings:
- - Other observations: skin erythema and oedema were reported in animals given 1 ml/kg bw. Skin erythema and ecchymosis were reported in animals given 2 ml/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- In a study probably similar to that described by OECD Test Guideline 402, triethoxy(3-isocyanatopropyl)silane was harmful to male rabbits following a 24-hour acute dermal administration. An acute dermal LD50 of 1.26 ml/kg bw [1261 mg/kg bw] was derived.
- Executive summary:
Two summary reports described an acute dermal toxicity study in rabbits, probably similar to that described by OECD Test Guideline 402 (acute dermal toxicity), with triethoxy(3-isocyanatopropyl)silane.
Groups of four male albino rabbits were exposed to undiluted triethoxy(3-isocyanatopropyl)silane at 1 or 2 ml/kg bw under occlusion for 24 hours. Rabbits were observed for 14 days for mortality and clinical signs of toxicity, before sacrifice and necropsy to identify any gross pathological changes.
One and four animals died in the low and high dose groups respectively. Congestion was noted in the lungs, as well as paleness and mottling in livers and kidneys, and pale spleens. Irritability and rapid breathing were noted in animals from the top dose group within the first few hours of treatment. Skin erythema was seen in all treated animals, while ecchymosis [haemorrhagic spots] was seen in animals treated with 2 ml/kg bw, and oedema in animals given 1 ml/kg bw.
Triethoxy(3-isocyanatopropyl)silane was harmful to male rabbits and an acute dermal LD50 of 1.26 ml/kg bw [1240 mg/kg bw] was derived.
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