Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 619-646-5 | CAS number: 1067-87-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 Jan 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: study according to the guideline under GLP. Study does not allow definitive conclusion
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Diethyl allylphosphonate
- EC Number:
- 619-646-5
- Cas Number:
- 1067-87-4
- Molecular formula:
- C7H15O3P
- IUPAC Name:
- Diethyl allylphosphonate
- Test material form:
- other: liquid
- Details on test material:
- Identification: Diethyl Allylphosphonate
Appearance/Physical State: Clear colorless liquid
Storage Conditions: Room temperature in the dark
Constituent 1
Test system
- Vehicle:
- other: 0.9% w/v sodium chloride solution
- Amount / concentration applied:
- Test item: as such
Positive control: ethanol > 98.8%
Negative control:0.9% w/v sodium chloride. - Duration of treatment / exposure:
- 10 min
- Details on study design:
- Bovine corneas were obtained from a local abatoir, preserved in HBBS and prepared on arrival in the laboratory. Corneas free of damage were mounted in a closed BCOP holder. Both chambers were filled with MEM and incubated for 60 minutes at 32 ± 1 ºC.
In the test undamaged corneas (3/treatment) were checked for opacity (zero measurement) and exposed to 0.75 mL the test substance, negative or positive control (anterior chamber) at 32 ± 1 ºC for 10 minutes. After exposure the chambers and corneas were rinsed and chambers were filled with fresh MEM. Corneas were checked visually and opacity was assessed after incubation for 120 min at 32 ± 1 ºC. In additon the corneas were exposed to sodium fluorin (4 mg/L) (anterior chamber) for 90 minutes. Optical density at 492 nm of the medium in the posterior chamber was measured to assess permeability.
Measurements for opacity were corrected for the initial opacity and the opacity measured in the vehicle controls.
Measurements for permeability were corrected for vehicle control.
All results were averaged.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: IVIS
- Score:
- 25.4
- Remarks on result:
- other: mean opacity value + (15 x mean OD492 value)
Any other information on results incl. tables
|
Opacity Post incubation – pre-treatment |
Opacity corrected |
Permeability |
Permeability corrected |
IVIS |
Neg control |
1 |
|
0.072 |
|
|
|
2 |
|
0.043 |
|
|
|
1 |
|
0.058 |
|
|
|
Mean 1.3 |
|
Mean 0.058 |
|
2.2 |
Pos control |
30 |
28.7 |
1.495 |
1.437 |
|
|
27 |
25.7 |
1.490 |
1.432 |
|
|
24 |
22.7 |
1.298 |
1.240 |
|
|
|
Mean 25.7 |
|
Mean 1.370 |
46.2 |
Test substance |
21 |
19.7 |
0.398 |
0.340 |
|
|
15 |
13.7 |
0.385 |
0.327 |
|
|
25 |
23.7 |
0.671 |
0.613 |
|
|
|
Mean 19.0 |
|
Mean 0.427 |
25.4 |
Applicant's summary and conclusion
- Interpretation of results:
- other: no prediction can be made
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The outcome of the BCOP test with the substance shows that no prediction on the eye irritation of the substance can be made.
- Executive summary:
The substance is tested in the in vitro BCOP assay. The calculated IVIS based on assessments of opacity and permeability for the test substance is 6.1. This does not allow a definitive conclusion on the irritant properties of the test substance, but indicates that the substance is not causing serious eye damage.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.