Registration Dossier
Registration Dossier
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EC number: 203-860-7 | CAS number: 111-34-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions. Restriction: purity of TS not reported; non-fasted animals; no data about vehicle; no data about clinical signs, necropsy or body weight.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List V.
- Author:
- Smyth HF, Carpenter CP, Weil CS, Pozzani U
- Year:
- 1 954
- Bibliographic source:
- Arch Ind Hyg Occ Med 10: 61-68
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Butyl vinyl ether
- EC Number:
- 203-860-7
- EC Name:
- Butyl vinyl ether
- Cas Number:
- 111-34-2
- Molecular formula:
- C6H12O
- IUPAC Name:
- 1-(ethenyloxy)butane
- Details on test material:
- Butyl vinyl ether, no further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Male Carworth-Wistar rats were used, 90 to 120 g in weight. Animals were kept on complete diet.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- Rats not fasted before dosing; application volume 1-10 mL
- Doses:
- Dose levels were arranged in a logarithmic series differing by a factor of 2 (no further details).
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Post exposure observation period 14 days
- Statistics:
- LD50-values were estimated by the method of Thompson using the tables of Weil, based on mortalities.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 10 300 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: limits of +-1.96 standard deviations (calculated according to Thompson): 8400-12630 mg/kg bw
- Mortality:
- no further details
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
- Conclusions:
- The LD50 in male Wistar rats was 10300 mg/kg bw; the post exposure observation period was 14 days. The Limit dose according to OECD TG401 is 5000 mg/kg bw.
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