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Registration Dossier
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Diss Factsheets
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EC number: 942-697-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The test item is the substance in water at 30g/l
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction mass of 1,3'-Bipyridinium, 1'-[3-(dimethylamino)propyl]-6'-hydroxy-4'-methyl-2'-oxo-, inner salt and 1,3'-Bipyridinium, 1'-[3-(dimethylamino)propyl]-1',6'-dihydro-2'-hydroxy-4'-methyl-6'-oxo-, chloride (1:1)
- Molecular formula:
- not applicable (reaction mass)
- IUPAC Name:
- Reaction mass of 1,3'-Bipyridinium, 1'-[3-(dimethylamino)propyl]-6'-hydroxy-4'-methyl-2'-oxo-, inner salt and 1,3'-Bipyridinium, 1'-[3-(dimethylamino)propyl]-1',6'-dihydro-2'-hydroxy-4'-methyl-6'-oxo-, chloride (1:1)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Test system: Rat, Hanibm: WIST (SPF)
Rationale Recognized by the international guidelines as the recommended test system (e.g. DECO, EEC).
Source BRL, Biological Research Laboratories Ltd. Wolferstrasse 4 CH-4414 Fullinsdorf
Number of animals per group: 3 males + 3 females
Total number of animals: 3 males + 3 females
Age at start of treatment: males : 8 weeks / females: 10 weeks
Body weight at start of treatment: males : 174 - 196 g / females: 174 - 188 g
Identification: By unique cage number and corresponding color-coded spots.
Randomization : Randomly selected at time of delivery in groups of three.
Acclimatization : One week under laboratory conditions after veterinary examination.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- bi-distilled water
- Details on oral exposure:
- The animals received the test article on a mg/kg body weight base by oral gavage after being fasted for 12 to 18 hours (access to water was not interrupted).
Food was again presented approximately 3 to 4 hours after dosing.
Application Volume/kg body weight: 10 ml at 2000 mg/kg - Doses:
- The test article was placed into a glass beaker on a tared Mettler PM 480
balance and the vehicle, (bi-distilled water) was added. A weight by volume
dilution was prepared using a homogenizer (Ultra-Turrax, Janke and Kunkel,
D-7813 Staufen).
Homogeneity of the test article in the vehicle was maintained during treatment
using a magnetic stirrer (Janke and Kunkel, D-7813 Staufen).
The preparation was made immediately prior to dosing. - No. of animals per sex per dose:
- 3
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- no death
- Clinical signs:
- other: no clinical signs noted
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- the test item has an acute oral LD50 > 2000 mg/kg bw
- Executive summary:
The following death rate was observed:
0 % at 2000 mg/kg body weight
Based on these observations, the estimated acute oral toxicity of HMDPY
in rats of both sexes observed for a period of 15 days is: greater than 2000 mg/kg
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