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EC number: 247-104-4 | CAS number: 25564-22-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study similar to guideline. Limited information (e.g. purity)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Version / remarks:
- (According to the Method of Magnusson and Kligman, but pre-dating adoption by OECD as part of TG406)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- (The study pre-dates the introduction of GLP in the UK)
- Type of study:
- guinea pig maximisation test
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- male/female
- Details on test animals and environmental conditions:
- Albino Dunkin/Hartley guinea pigs are bred in Environmental Safety Division are used. They are selected for the preliminary irritation tests and for the sensitisation test according to weight and sex.
- Route:
- intradermal
- Vehicle:
- other: i) injection induction solution: 0.01% Dobs/saline; ii) application induction solution: ethanol; iii) application challenge solution: ethanol
- Concentration / amount:
- i) induction (intradermal injection): 0.2%
ii) induction (covered patch application): 25%
ii) challenge (covered patch application): 5% - Route:
- epicutaneous, occlusive
- Vehicle:
- other: i) injection induction solution: 0.01% Dobs/saline; ii) application induction solution: ethanol; iii) application challenge solution: ethanol
- Concentration / amount:
- i) induction (intradermal injection): 0.2%
ii) induction (covered patch application): 25%
ii) challenge (covered patch application): 5% - No. of animals per dose:
- Ten test guienea pigs weighing about 320 g are selected. There are either 6 males and 4 females or vice versa.
- Challenge controls:
- Two types of controls are used:
Treated controls: 4 guinea pigs of the same sex are given mock induction treatment at the time tme and in the same way as for the test animals except that the test substance is omitted from the injection and application preparation.
Untreated controls: At every challenge in the test 4 previously untreated animals of the same sex and weighing approximately the same as the test animals at that challenge are treated in exactly the same was as the test animals. - Positive control substance(s):
- no
- Positive control results:
- no data
- Reading:
- other: challenge 1
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 5%
- No. with + reactions:
- 6
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: other: challenge 1. . Hours after challenge: 24.0. Group: test group. Dose level: 5%. No with. + reactions: 6.0. Total no. in groups: 10.0.
- Reading:
- other: challenge 1
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 5%
- No. with + reactions:
- 3
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: other: challenge 1. . Hours after challenge: 48.0. Group: test group. Dose level: 5%. No with. + reactions: 3.0. Total no. in groups: 10.0.
- Reading:
- other: challenge 2
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 5%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: other: challenge 2. . Hours after challenge: 24.0. Group: test group. Dose level: 5%. No with. + reactions: 0.0. Total no. in groups: 10.0.
- Reading:
- other: challenge 2
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 5%
- No. with + reactions:
- 2
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: other: challenge 2. . Hours after challenge: 48.0. Group: test group. Dose level: 5%. No with. + reactions: 2.0. Total no. in groups: 10.0.
- Reading:
- other: challenge 3
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 5%
- No. with + reactions:
- 1
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: other: challenge 3. . Hours after challenge: 24.0. Group: test group. Dose level: 5%. No with. + reactions: 1.0. Total no. in groups: 10.0.
- Reading:
- other: challenge 3
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 5%
- No. with + reactions:
- 2
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: other: challenge 3. . Hours after challenge: 48.0. Group: test group. Dose level: 5%. No with. + reactions: 2.0. Total no. in groups: 10.0.
- Reading:
- other: challenge 4
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 5%
- No. with + reactions:
- 1
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: other: challenge 4. . Hours after challenge: 24.0. Group: test group. Dose level: 5% . No with. + reactions: 1.0. Total no. in groups: 10.0.
- Reading:
- other: challenge 4
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 5%
- No. with + reactions:
- 1
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: other: challenge 4. . Hours after challenge: 48.0. Group: test group. Dose level: 5%. No with. + reactions: 1.0. Total no. in groups: 10.0.
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information weak to moderate sensitiser Criteria used for interpretation of results: expert judgment
- Conclusions:
- 2-Pentylcyclopentenone was found to be a weak/moderate sensitiser in a guinea pigmaximisation test, according to the method of Magnusson and Kligman.
- Executive summary:
In an in vivo guinea pig maximisation test, according to the method of Magnusson and Kligman but conducted prior to the introduction of GLP or the applicable OECD test guideline. 2 -Pentylcyclopentanone was found to be a weak/moderate sensitiser, 6/10 guinea pigs sensitised after one challenge.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
- Migrated from Short description of key information:
Pentyl cyclopentenone was found to be a weak/moderate sensitiser in two guinea pig maximisation test.
Justification for selection of skin sensitisation endpoint:
Reliable in vivo study
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on positive results in two in vivo skin sensitisation studies, classification under the EU DSD or CLP is required.
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