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EC number: 810-388-0 | CAS number: 12067-23-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Expert Statement
- Adequacy of study:
- key study
- Study period:
- 2015-11-23
Data source
Reference
- Reference Type:
- other: Expert Statement
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test material
- Reference substance name:
- tin(4+) λ²-tin(2+) trisulfanediide
- EC Number:
- 810-388-0
- Cas Number:
- 12067-23-1
- Molecular formula:
- Sn2S3
- IUPAC Name:
- tin(4+) λ²-tin(2+) trisulfanediide
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: no bioaccumulation potential based on study results
- Executive summary:
Based on the physical form and low water solubility, but mainly on the absence of toxicity in acute and repeated dose oral toxicity studies, oral absorption of tin sulfides and in this case ditin trisulfide (Tin (II,IV) sulfide) is assumed to be very low. This conclusion is confirmed by the literature on oral absorption of inorganic tin compounds.
Due to the physical state, the molecular weight, the low water solubility, the vapour pressure, but mainly the absence of toxicity in acute dermal animal testing and the absence of irritating or corrosive and sensitizing potential the dermal absorption of tin sulfides and in this case ditin trisulfide is assumed to be very low.
Even if the particle size and the low water solubility favour the assumption that particle can be absorbed on different stages of the stages of the respiratory tract the low vapour pressure and the tendency of ditin trisulfide particles to agglomerate and depositas well as the absence of clear systemic toxicity in acute toxicity studies with tin sulfides do not favour the respiratory uptake.
Based on the low water solubility, but mainly based on the absence of target organs or signs of toxicity in an acute and a repeated dose toxicity study with tin sulfides in rats up to the limit concentration, distribution of tin sulfides and in this case ditin trisulfide was considered minimal. Even if literature describes that tin may accumulate mainly in bones, but also in kidneys, liver and lung this is assumed to be of minor interest for insoluble tin sulfides, e.g. ditin trisulfide,due to the low absorption.
There is no direct indication of relevant bioaccumulation potential of tin sulfides, e.g.ditin trisulfide. However, literature describes that tin may accumulate mainly in bones, but also in kidneys, liver and lung. But it has been shown that water soluble tin salts are eliminated within short half-times. Taking into account that absorption of insoluble tin sulfides in this case ditin trisulfideis considered to be very low, accumulation is not considered to be relevant.
The oral absorptionof tin sulfides and in this case ditin trisulfideis very low, therefore the estimated favoured excretion route is the faecal route. However, very small quantities of absorbed and therefore dissolved parts are excreted via urine and bile. This is confirmed by literature.
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