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Diss Factsheets
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EC number: 201-121-3 | CAS number: 78-50-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- Apr. 21, 1986 to May 5, 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to a method comparable to OECD guideline 402 and conducted according to GLP. It is a read across study, hence maximum reliability rating of 2 assigned according to ECHA guidance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- A mixture of: hexyldioctylphosphineoxide; dihexyloctylphosphineoxide; trioctylphosphineoxide
- IUPAC Name:
- A mixture of: hexyldioctylphosphineoxide; dihexyloctylphosphineoxide; trioctylphosphineoxide
- Reference substance name:
- A mixture of: hexyldioctylphosphineoxide; dihexyloctylphosphineoxide; trioctylphosphineoxide
- EC Number:
- 403-470-9
- EC Name:
- A mixture of: hexyldioctylphosphineoxide; dihexyloctylphosphineoxide; trioctylphosphineoxide
- IUPAC Name:
- 403-470-9
- Test material form:
- other: Liquid
- Details on test material:
- - Name of the test substance (as cited in the report): CYANEX® 923 Extractant
- Lot number: 860-12,13, CT-229-85
- Physical state: clear liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Source: an FDRL-and USDA approved supplier.
- Age at Initiation: young adult.
- Identification: ear tag, color coded cage tag.
- Housing: individually housed in wire-mesh bottom cages
- Feed: NIH 09 Rabbit Ration, ad libitum, supplied fresh daily
- Water: tap water, ad libitum. Monitored for contaminants at periodic intervals according to FDRL Standard Operating Procedures.
- Photoperiod: 12 h light/dark cycle
- Weight before the beginning of the test: 2-3 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The back of each rabbit was clipped with an electric clipper on the day prior to dosing. The test substance was topically applied to the non-abraded dorsal skin at a dose level of 2,000 mg/kg bw. The test sites were wrapped with an occlusive binder consisting of a layer of plastic wrap and stockinette sleeve held in place with tape. The binders were removed 24 h post-dose administration and the exposure sites gently wiped with gauze to remove as much non-absorbed test substance as possible.
- Duration of exposure:
- 24 h
- Doses:
- 2,000 mg/kg bw
- No. of animals per sex per dose:
- 5/sex
- Details on study design:
- - Duration of observation period following administration: 14 d
- Frequency of observations and weighing: mortality and toxicity signs were recorded three times on the day of dosing and twice daily thereafter. Individual body weight data were recorded on Day 1, (prior to dose-administration) 8 and 15.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred during the whole study.
- Clinical signs:
- other: All animals exhibited well-defined erythema and edema at study Day 2. Eschar formation was noted in all animals by study Day 4. Diarrhea, soft stools and nasal discharge were sporadically noted from study Day 2. These findings are common among laboratory
- Gross pathology:
- No internal lesions or abnormalities were noted in any animal at study termination. The test site of all animals exhibited prominent subcutaneous vascularization.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 of the test substance was found to be >2,000 mg/kg bw in New Zealand White rabbits (Busch BA, 1986).
- Executive summary:
A study was conducted in rabbits to evaluate the acute dermal toxicity of the read across substance ‘A mixture of: hexyldioctylphosphineoxide; dihexyloctylphosphineoxide; trioctylphosphineoxide’ in a method equivalent to the OECD Guideline 402, in compliance with GLP. The back of each rabbit was clipped with an electric clipper on the day prior to dosing. The test substance was topically applied to the non-abraded dorsal skin at a dose level of 2,000 mg/kg bw. The test sites were wrapped with an occlusive binder consisting of a layer of plastic wrap and stockinette sleeve held in place with tape. The binders were removed 24 h post-dose administration and the exposure sites gently wiped with gauze to remove as much non-absorbed test substance as possible. The observation period after the dermal administration lasted for 14 d. Mortality and toxicity signs were recorded three times on the day of dosing and twice daily thereafter. Individual body weight data were recorded on Days 1 (prior to dose-administration), 8 and 15. All animals killed at the termination of the study were subjected to gross necropsy. Under the study conditions, the acute dermal LD50 of the test substance was found to be >2,000 mg/kg bw in New Zealand White rabbits (Busch BA, 1986).
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