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EC number: 942-764-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
One acute oral study, one acute inhalation study and one acute dermal study were performed with the test substance.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP study.
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- In this acute oral range finding study, 6 males albino rats were used to performed the expriment. 2 rats for each dose levels were used (1000 / 3000 / 10000 mg/kg). Clinical signs, mortality and body weight were recorded.
- GLP compliance:
- no
- Test type:
- other: No data
- Limit test:
- no
- Species:
- rat
- Strain:
- other: Albino rats
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No data
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- Form administred: 25.0% (w/v) suspension in corn oil.
- Doses:
- 1000 / 3000 and 10000 mg/kg
- No. of animals per sex per dose:
- 2 males for each dose level.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: At test day 0 and test day 14 for the surviving
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight. - Statistics:
- No data
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 - < 3 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- - At 1000 mg/kg: 0 percent dead.
- At 3000 mg/kg: 100 percent death after 30 minutes after administration.
- At 10000 mg/kg: 100 percent death (the first one 30 minutes after administartion and 15 minutes after administration for the second) - Clinical signs:
- other: - At 1000 mg/kg: Hypoactivity, gasping, pilo-erection. - At 3000 mg/kg: Hypoactivity, gasping, abdominal griping, pilo-erection, convulsions. - At 10000 mg/kg: Hypoactivity, gasping, abdominal griping, pilo-erection, convulsions.
- Gross pathology:
- Gross pathology finding: Necropsy examination of the animals that died revealed hemorrhaged stomachs. No gross pathologic alterations were noted among the animals sacrified at the end of the 14-day observation period.
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In the acute oral toxicity experiment, the LD50 was determined to be > 1000 mg/kg <3000 mg/kg.
- Executive summary:
In the acute oral range finding study, 6 males albino rats were used.
2 rats for each dose levels were used (1000 / 3000 / 10000 mg/kg).
The test material was suspended in corn oil before administration to the rats.
Mortality
- At 1000 mg/kg: 0 percent dead.
- At 3000 mg/kg: 100 percent death after 30 minutes after administration.
- At 10000 mg/kg: 100 percent death (the first one 30 minutes after administartion and 15 minutes after administration for the second)
Clinical signs:
- At 1000 mg/kg: Hypoactivity, gasping, pilo-erection.
- At 3000 mg/kg: Hypoactivity, gasping, abdominal griping, pilo-erection, convulsions.
- At 10000 mg/kg: Hypoactivity, gasping, abdominal griping, pilo-erection, convulsions.
In conclusion, in the acute oral toxicity experiment, the LD50 was determined to be > 1000 mg/kg <3000 mg/kg.
Reference
Reactions:
Dose (mg/kg) | Reaction | Time of onset following dose administration | Duration of reaction | Time of death following dose administration | |
1 000 | Hypoactivity | 5 minutes | 6 -22 hours | / | |
1 000 | Gasping | 5 minutes | 10 minutes | / | |
1 000 | Pilo-erection | 5 minutes | 6 -22 hours | / | |
3 000 | Hypoactivity | 5 minutes | Until death | 30 minutes | |
3 000 | Gasping | 5 minutes | Until death | 30 minutes | |
3 000 | Abdominal griping | 5 minutes | Until death | 30 minutes | |
3 000 | Pilo-erection | 15 minutes | Until death | 30 minutes |
|
3 000 | Convulsions | 15 minutes | Until death | 30 minutes | |
10 000 | Hypoactivity | 5 minutes | Until death | 15 -30 minutes | |
10 000 | Gasping | 5 minutes | Until death | 15 -30 minutes | |
10 000 | Abdominal griping | 5 minutes | Until death | 15 -30 minutes | |
10 000 | Pilo-erection | 15 minutes | Until death | 15 -30 minutes |
|
10 000 | Convulsions | 15 minutes | Until death | 15 -30 minutes |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 000 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP study.
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- This acute dust inhalation toxicity study was conducted wherein a group of ten albino rats was exposed to a dust of the test item for four hours in a 70 -liter inhalation chamber. The average analytical concentration was 1.05 mg/L air. After exposure, the test animals were observed for 14 days.
- GLP compliance:
- no
- Test type:
- other: not available
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: Albino rats
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- 10 albino rats were used.
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure chamber volume: 70-liter inhalation chamber - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- 1.05 mg/L air
- No. of animals per sex per dose:
- 10 albino rats
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 1.05 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- There were no death during the inhalation exposure or observation period.
- Clinical signs:
- other: Untoward bahavioral reactions exhibited by the rats included hypoactivity, lacrimation and conjunctivitis.
- Body weight:
- Body weight gains of nine out of ten rats were normal.
- Gross pathology:
- Necropsy examinations, performed on all rats at the termination of the two weeks observation period revealed two test rats with tan nodules on all lobes of the lungs. All other finding in the test animals were essentially the same as in stock animals taken from the same group as the test rats.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LC50 is greater than 1.05 mg/L air in rats.
- Executive summary:
An acute dust inhalation toxicity study was conducted wherein a group of ten albino rats was exposed to a dust of the test material for four hours in a 70 -liter inhalation chamber. The avrage analytical concentration was 1.05 mg/L air. After exposure, the test animals were observed for 14 days.
Untoward behavioral reactions exhibited by the test animals during exposure included lacrimation, hypoactivity and conjunctivitis. No deaths were noted during the exposure or the two-week observation period. Body weight gains were normal except for one rat.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating conc.
- Value:
- 1 050 mg/m³ air
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP study. The experiment was performed according to the guideline equivalent or similar to the OECD 402 (Acute dermal toxicity).
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rabbit
- Strain:
- other: Albinos rabbits
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 6 albinos rabbits (3males and 3 females)
- Type of coverage:
- not specified
- Vehicle:
- other: Test material was applied to premoistened skin.
- Duration of exposure:
- 24 hours
- Doses:
- 300/ 1000 / 3000 mg/g
- No. of animals per sex per dose:
- Two animals for each dose level (one male and one female)
- Control animals:
- not specified
- Details on study design:
- Test item was applied at each dose level on one abraded and one intact animal.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 other: mg/kg
- Based on:
- test mat.
- Mortality:
- No mortality
- Clinical signs:
- other: The rabbits did not exhibit any unusual behavioral reactions following dermal exposure. Local skin recation after 24-hour exposure period were characterized by barely perceptible pale to red erythema. No skin reaction were noted at 7 and 14 days.
- Gross pathology:
- Necropsy examination of all rabbits sacrified at the end of the 14-day observation period, did not reveal any gross pathologix alterations.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute LD50 of the test material was determined to be greater than 3000 mg/kg.
- Executive summary:
Three males and three females albinos rabbits were used to detemined the acute dermale toxicity of the test material.
Two animals for each dose level (one male and one female): 300 / 1000 and 3000 mg/kg.
Test item was applied at each dose level on one abraded and one intact animal.
The observation period is 14 days after 24 hours exposure duration.
The rabbits did not exhibit any unusual behavioral reactions following dermal exposure. Local skin recation after 24-hour exposure period were characterized by barely perceptible pale to red erythema. No skin reaction were noted at 7 and 14 days.
Necropsy examination of all rabbits sacrified at the end of the 14-day observation period, did not reveal any gross pathologix alterations.
No mortality occured during the observation time.
The acute LD50 of the test material was dezermined to be greater than 3000 mg/kg.
Reference
Mortality and body weight:
Dose* (mg/kg) | Animal N° and sex | Individual bodyweight (kg) at test day 0 | Individual bodyweight (kg) at test day 14 | Number dead/ Number tested | Percent dead |
300 | 1 -M** 2 -F |
2.86 2.64 |
2.70 2.98 |
0/2 | 0 |
1000 | 3-M** 4 -F |
2.90 2.44 |
2.80 2.56 |
0/2 | 0 |
3000 | 5-M** 6 -F |
2.98 3.18 |
2.96 3.14 |
0/2 | 0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
The acute oral toxicity study was performed in male rats and the test substance was applied at a dose level of 1000, 3000 and 10000 mg/kg. All animals died at the dose level of 3000 and 10000 mg/kg whereas no death occurred at the dose level of 1000 mg/kg. The Oral LD50 was therefore considered to be >1000 < 3000 mg/kg.
An acute inhalation study was performed with the test substance. The test substance was applied during 4 -hours to male rats at a measured average concentration of 1.05 mg/L air. No death occured during the study and following observation period. The Acute Inhalation LC50 is greater than 1.05 mg/L air.
An acute dermal toxicity was conducted with albino rabbits at a dose level of 300, 1000 and 3000 mg/kg. The substance was applied to the intact skin during 24 hours and no death occured during the study and following observation period. The acute dermal LD50 in rabbit is considered to be greater than 3000 mg/kg.
Justification for selection of acute toxicity – oral endpoint
only existing study
Justification for selection of acute toxicity – inhalation endpoint
Only existing study
Justification for selection of acute toxicity – dermal endpoint
Only existing study
Justification for classification or non-classification
- oral toxicity:
Based on the above stated assessment of the acute oral toxicity the substance does need to be classified as Acute Oral toxicity Category 4 according to Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC) and accordingCLP (Regulation (EC) No 1272/2008 Of The European Parliament And Of The Council)as implementation of UN-GHS in the EU.
- dermal toxicity:
Based on the above stated assessment of the acute dermal toxicity of the substance (absence of toxicity up to 3000 mg/kg) the substance does not need to be classified according to Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC) and accordingCLP (Regulation (EC) No 1272/2008 Of The European Parliament And Of The Council)as implementation of UN-GHS in the EU.
- inhalation toxicity:
Based on the above stated assessment of the acute inhalation toxicity of the substance (absence of toxicity up to 1.05 mg/L) the substance does not need to be classified according to Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC) and accordingCLP (Regulation (EC) No 1272/2008 Of The European Parliament And Of The Council)as implementation of UN-GHS in the EU.
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