Registration Dossier
Registration Dossier
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EC number: 226-403-3 | CAS number: 5394-63-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981-08-03 to 1981-08-17
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No test Guideline is mentioned. Acceptable for reliability but not in detail documented.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- not specified
- Principles of method if other than guideline:
- According to SOP # 11.1.4
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Diketen-Acetone-Adduct
- IUPAC Name:
- Diketen-Acetone-Adduct
- Test material form:
- other: liquid
- Details on test material:
- Liquid samples will be applied to the skin as undiluted.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- 5000 mg/kg bw
3200 mg/kg bw
2000 mg/kg bw
1300 mg/kg bw
800 mg/kg bw - No. of animals per sex per dose:
- 6 male animals per dose
- Control animals:
- yes, concurrent no treatment
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 5 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
No gross changes observed in any animal.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test substance is considered to be non-toxic by a single dermal application. The LD50 is greater than 5000 mg/kg bw.
- Executive summary:
The acute dermal tox study was performed in year 1981. 6 male New Zealand White rabbits per dose were used for the test.
The test substance is considered to be non-toxic by a single dermal application. The LD50 is greater than 5000 mg/kg bw.
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