Registration Dossier

Administrative data

Description of key information

Not corrosive to skin. Not a skin irritant.
Not corrosive to eyes, however, it is an eye irritant.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin irritation:

Following exposure to Benzyl Salicylate (Target Substance) and the Source Substance, Cyclohexyl Salicylate, via contact with skin the substance is considered not to be a skin irritant to rabbits.

Eye irritation:

An in vitro (BCOP) study on the substance, Benzyl salicylate, indicates that the substance is not corrosive to eyes or a severe eye irritant.

In the in vivo study, Benzyl Salicylate is considered to be an irritant to the eyes of rabbits. Irritation (redness) in 2 out of 3 animals is sufficient to classify the substance in accordance with CLP. According to guidance, as the effects observed are fully reversible within 7 days (3 days for Benzyl Salicylate), the substance is considered to be mildly irritating to eyes (category 2B).

For classification and labelling purposes this indicates that the structural analogue is relatively harmless and would not, in itself, be classified in accordance with Regulation (EC) No 1272/2008 (CLP). The registration substance is considered to have similar properties and is therefore not classified in accordance with CLP.


Justification for selection of skin irritation / corrosion endpoint:
Following exposure to Benzyl Salicylate (Target Substance) and the Source Substance, Cyclohexyl Salicylate, via contact with skin the substance is considered not to be a skin irritant to rabbits.

Justification for selection of eye irritation endpoint:
Benzyl Salicylate (Target Substance) was considered not to be an ocular corrosive or severe irritant, in vitro (BCOP) in a K1 rated GLP/ OECD test guideline study.
Benzyl Salicylate is considered, however, to be an irritant to the eyes of rabbits. Irritation (redness) in 2 out of 3 animals is sufficient to classify the substance in accordance with CLP (category 2B).

Effects on eye irritation: slightly irritating

Justification for classification or non-classification