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Diss Factsheets
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EC number: 209-406-4 | CAS number: 577-11-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in soil
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in soil
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- The study was not conducted under GLP, although a LIMS was used to produce and stored the data
- Qualifier:
- according to guideline
- Guideline:
- other: equivalent or similar other guideline: DIN 38414 Teil 8
- Principles of method if other than guideline:
- A defined quantity of the test item was added to the inocculum
- GLP compliance:
- no
- Remarks:
- Data were produced and documents according to WinLims-Nr P-0705665
- Test type:
- other: anaerobic degradation in STP digester tower
- Oxygen conditions:
- anaerobic
- Soil classification:
- other: digested sludge was used
- Year:
- 2 007
- Details on soil characteristics:
- Sludge from STP Düsseldorf-Süd (domestic) which was digested almost completely (age of sluge: almost 27 days). The sludge was spiked with 5% concentrated raw sludge (aerobic)to maintain viability of microorganisms (zoogloea)
- Soil No.:
- #1
- Duration:
- 50 d
- Soil No.:
- #1
- Initial conc.:
- 174.4 other: mg per 500 mL slude
- Based on:
- other: TOC
- Soil No.:
- #1
- Initial conc.:
- 404 other: mg per 500 mL sludge
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- TOC removal
- Soil No.:
- #1
- Temp.:
- 35
- Microbial biomass:
- 500 mL digested sludge with unknown composition
- Details on experimental conditions:
- 500 mL reactors were used to conduct the test.
Two test groups were set-up (in duplicate): Test concentration & blank control, i.e., digested sludge without test substance.
The pH of the inocculum was adjusted to pH 7 (plus/minus 0.2) by adding an appopriate buffer (acc. to EN 12176, Part 5).
Test substance and inocculum were filled into the reactord anaerobically and homogenized prior to connecting to the Eudiometer.
During the test, samples were mixed once a day.
Volumes of digester gas were analysed daily (without few exceptions)
- DT50:
- ca. 40 d
- Type:
- other: Graphical estimation
- Details on results:
- 77% of the test item were degraded within 21 days, after a lag phase of 29 days
- Conclusions:
- The results show that 77% of the test substance was degraded to CO2 and methane, within 21 days, following a lag phase of 29 days.
- Executive summary:
Following DIN 38414 Part 8, the test substance was incubed under anaerobic conditions for 50 days. Sludge, which had been digested almost completely at domestic STP Düssedorf-Süd, was mixed with 5% raw, aerobic sludge from the same STP. The thus combined sludge was mixed with the test item, 174.4 mg TOC/L sludge. The specimen were incubated at 35 plus/minus 1°C in 500 mL reactor, attached to the following system: Behrotest Eudiometer Unit FH 10 acc. to DIN 38414 S8. Test solutions were homogenized at the beginning of the test and one daily therafter. Digester gaz volumes were measured daily in treatment and control test group. CO2 was removed by precipitation through alkaline solutions. Volumes of methane, released from test group and control were compare with each other. Total incubation time was 50 days. The results showed that 77% of the test item were degraded within 21 days following a lag phase of 29 days. The test is considered valid, since the blank sludge volume produced 849 mL digester gas, which is well comparable with the STP digester tower production performance (600 to 1500 mL per comparable quantity of inocculum).
- Endpoint:
- biodegradation in soil: simulation testing
- Data waiving:
- other justification
- Justification for data waiving:
- the study does not need to be conducted because the substance is readily biodegradable
Referenceopen allclose all
Description of key information
In accordance with EC 1907/2006, Annex IX, point 9.2.1.3, column 2, soil simulation testing is not required since Docusate Sodium is readily biodegradable, as shown in study section 4.1.2.1.2 and since (2) Docusate Sodium is not considered highly adsorptive to soil (Koc 953 L/kg).
Key value for chemical safety assessment
Additional information
One study is available, which investigated the anaerobic degradation of Docusate Sodium to methane during a digestion tower simulation test, with the purpose to assess whether use of digested sludge in agriculture poses a risk for the soil environment (Cognis, Bendt 2007). The study however demonstrates that Docusate Sodium is biodegradable under anaerobic conditions, since 77% were digested within 21 days, after the sludge had been adapted. The adaptation period duration was four weeks.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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