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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 215-211-5 | CAS number: 1313-82-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
General
A literature search and evaluation programme on animal and human genetic toxicity data of sodium sulfide and sodium hydrogensulfide has been conducted. All data sources were assessed by expert toxicologists for quality and reliability, as well as relevance for regulatory risk assessment under REACH. The results are attached to the technical dossier in atabular report (IUCLID section 13).
Results:
All three available studies performed with sodium sulfide yielded negative results concerning genetic toxicity:
- in a reliable in-vitro HPRT test (Stone_2010) it is concluded that sodium sulfide, anhydrous did not induce mutation at thehprtlocus of mouse lymphoma cells when tested under the conditions employed in this study.
- in a reliable in-vitro Ames test (reverse gene mutation assay) reported by Engelhardt_1989 it is concluded that sodium sulfide is not mutagenic under the experimental conditions.
- a reliable in-vivo micronucleus test (Gocke_1981) also gave had a negative result: no significant exerted mutagenic action was observed.
The REACH requirements according to the endpoints in section 8.4, Annex VII-X in Regulation (EC) 1907/2006 are fulfilled. No further testing is required.
Short description of key information:
In-vitro studies:
- The HPRT test (Covance_2010) performed with sodium sulfide (anhydrous) according to OECD guideline 476 was rated as RL=1 (reliable without restrictions) and used as a key study. The study had a negative result for induction of mutation at the hprt locus of mouse lymphoma cells.
- The key study on in vitro gene mutation of sodium sulfide (bacterial reverse mutation assay; Engelhardt_1989) was rated as reliable with restrictions and had a negative result for mutagenic properties.
In-vivo studies:
- Chromosome aberration of sodium sulfide has been tested in-vivo in a micronucleus assay performed in mice similar to OECD guideline 474 (Gocke_1981). This study was rated as reliable with restrictions (RL=2) and is used as a key study. The study had a negative result.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
All available reliable studies showed no genetic toxicity for sodium sulfide. Thus, no classification is required for sodium sulfide.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.