Registration Dossier
Registration Dossier
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EC number: 217-007-1 | CAS number: 1719-58-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data insufficient for assessment.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
- Principles of method if other than guideline:
- No guideline is specified and only limited details of the method are given in this brief report.
- GLP compliance:
- no
Test material
- Reference substance name:
- Chlorodimethylvinylsilane
- EC Number:
- 217-007-1
- EC Name:
- Chlorodimethylvinylsilane
- Cas Number:
- 1719-58-0
- Molecular formula:
- C4H9ClSi
- IUPAC Name:
- chloro(dimethyl)vinylsilane
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- no details
- Observation period (in vivo):
- no details, possibly 7 days
- Number of animals or in vitro replicates:
- no details
Results and discussion
In vivo
Results
- Irritation parameter:
- other: severe pain and tissue damage
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: The investigators suggest permanent injury is probable.
Any other information on results incl. tables
Treatment resulted in severe pain and tissue damage that did not subside within 7 days and was suggested to lead to permanent injury. The eyes were washed and unwashed - the effect of washing was not stated.
Applicant's summary and conclusion
- Conclusions:
- A very brief report of a possibly limited study found that the neat material (volume unspecified) applied to rabbit eyes caused severe pain and tissue damage that did not resolve within 7 days and was described as most likely leading to permanent injury
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