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Diss Factsheets
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EC number: 457-670-6 | CAS number: 157859-20-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
The key study for skin irritation in rabbits, conducted according to OECD test guideline 404 and in compliance with GLP, found the undiluted test material, tri(isopropyl)silyl acrylate, to be irritating to rabbit skin (RCC 2004c).
The key study for eye irritation in rabbits was conducted according to OECD Test Guideline 405 and in compliance with GLP. The undiluted test material, tri(isopropyl)silyl acrylate, was found not irritating to rabbit eyes (RCC 2005a).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The key skin irritation study for tri(isopropyl)silyl acrylate in rabbits, conducted according to OECD test guideline 404 and in compliance with GLP, found the undiluted test material to be irritating to rabbit skin (RCC, 2004c). Signs of irritation were seen at the 1, 24, 48 and 72 hour, 7 and 10 day time points, but these had disappeared by the 14 day time point. Scaling, evident from the 72 hour time point, persisted to the end of the observation period. No corrosive effects were noted. The test material was considered to be a Category 2 irritant due to the inflammation that persisted to the end of the 14 day observation period in all animals, specifically scaling.
The key eye irritation study for tri(isopropyl)silyl acrylate in rabbits was conducted according to OECD Test Guideline 405 and in compliance with GLP. The test material was found to be not irritating to rabbit eye (RCC, 2005a). Undiluted test material (0.1ml) was applied to the left eyes of 3 rabbits, with the right eyes serving as controls. Eyes were examined 1, 24, 48 and 72 hours after application. No corrosion of the cornea was evident during the study. Mild, early-onset and transient ocular changes (e.g. corneal opacity, reddening of the conjunctivae and sclerae and chemosis) were seen but these effects were reversible and were no longer evident 48 hours after treatment. No clinical signs of systemic toxicity, no mortality, no staining of the eye, and body weights considered to be within normal range of variability.
Justification for classification or non-classification
Based on available data on skin irritation, the registered substance, tri(isopropyl)silyl acrylate, is classified as Category 2 irritant, H315: 'Causes skin irritation' in accordance with Regulation (EC) No 1272/2008. The substance is not classified for eye irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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