Registration Dossier
Registration Dossier
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EC number: 203-718-4 | CAS number: 109-92-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions. Restriction: purity of TS not reported; non-fasted animals; no data about vehicle; no data about clinical signs, necropsy or body weight.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List VII.
- Author:
- Smyth HF, Carpenter CP, Weil CS, Pozzani U, Striegel JA, Nygum JS
- Year:
- 1 969
- Bibliographic source:
- Am Ind Hyg Assoc J 30: 470-476
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Methods according to Smyth et al., Am Ind Hyg Assoc J 23: 95ff (1962).
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Ethyl vinyl ether
- EC Number:
- 203-718-4
- EC Name:
- Ethyl vinyl ether
- Cas Number:
- 109-92-2
- Molecular formula:
- C4H8O
- IUPAC Name:
- ethoxyethene
- Details on test material:
- Ethyl vinyl ether, no further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Male Carworth-Wistar rats were used, four to five weeks of age and 90 to 120 g in weight. Animals were kept on complete diet.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- no further details
- Doses:
- Dose levels were arranged in a logarithmic series differing by a factor of 2.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Post exposure observation period 14 days
- Statistics:
- LD50-values were estimated by the method of Thompson using the tables of Weil, based on mortalities.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 6 150 mg/kg bw
- 95% CL:
- 5 300 - 7 150
- Remarks on result:
- other: original value: 8.16 mL/kg bw
Any other information on results incl. tables
No further details given. Density: 0.754 g/mL at 20°C.
Applicant's summary and conclusion
- Conclusions:
- The LD50 in male Wistar rats was 8.16 mL/kg bw corresponding to 6150 mg/kg bw; the post exposure observation period was 14 days.
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