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Diss Factsheets
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EC number: 605-296-0 | CAS number: 162627-17-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- : n-ocatnol was used instead of water
- GLP compliance:
- yes
- Key result
- Medium:
- n-octanol
- Solubility:
- > 400 g/L
- Temp.:
- 20 °C
- Test substance stable:
- ambiguous
Reference
Data obtained for the first set of samples indicated a steady increase in test substance concentration over the 72-hour equilibration period. Thus, a second set of samples was established and equilibrated for a minimum time of 72 h and a maximum of 120 h. Similarly, the results demonstrated an increasing solubility of test substance in n-octanol over the equilibration periods. Replicate variability for some sampling intervals is noted to be high with percent relative error reaching as much as 31%. While the measured concentration of the test material continued to rise through 120 h of testing, the measured concentration after 72 h reached the treatment level introduced in the experiment. Results at 120 h represent approximately 200% of the treatment concentration. The cause of these results is unknown. Instrumental response remained generally constant across the two experiments. Quality control samples were near 100% of the prepared concentration. Systemic bias cannot explain the high measured concentrations observed in test samples.
The technique used to measure the test material, gel permeation chromatography, provides separation based on molecular weight and structure. As possible reasons for the inconsistent analytical results the author discussed the formation of some quaternary structure with n-octanol on the idea of a conjugate or a change of the molecule caused by n-octanol. The result of either of these hypothetical events would lend itself to a change in the detector response as compared with calibration standards. Quality control samples were not exposed to n-octanol for the length of time or at the same temperatures as test samples.
Description of key information
> 400 g/L at 20°C (OECD 105, flask method)
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.