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Environmental fate & pathways

Hydrolysis

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Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
03 July 1992 to 06 August 1992
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: EEC guideline L 251/C.10. (1984)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Specific details on test material used for the study:
Product designation: Erionyl Rot HT 3728
Identification: FAT 45155/6 Vers. Nr.: TV1
Radiolabelling:
not specified
Analytical monitoring:
yes
Details on sampling:
no data
Buffers:
pH 4.0: Ciba-Geigy Code No. P07: 0.1 moles acetic acid and 0.1 moles sodium acetate were diluted to 1000 ml with water, and 60.0 ml 1.0 N HCl was added
pH 7.0: Ciba-Geigy Code No. P10: 0.041 moles disodium hydrogen phosphate and 0.028 mole potassium dihydrogen phosphate were diluted to 1000 ml with water
pH 9.0: Ciba-Geigy Code No. P12: 0.043 moles disodium tetraborate and 0.017 moles potassium dihydrogen phosphate were diluted to 1000 ml with water.
Details on test conditions:
Brown glass flasks were used.
The test was done at 50 °C at pH 4, 7 and 9.
Duration:
5 d
pH:
4
Temp.:
50 °C
Duration:
5 d
pH:
7
Temp.:
50 °C
Number of replicates:
duplicate samples were determined for each sampling
Positive controls:
no
Negative controls:
no
Preliminary study:
The hydrolysis of test substance at 50 °C was lower than 10 % at pH 4, 7 and 9.
Transformation products:
not measured
pH:
4
Temp.:
25 °C
DT50:
> 1 yr
Type:
(pseudo-)first order (= half-life)
pH:
7
Temp.:
25 °C
DT50:
> 1 yr
Type:
(pseudo-)first order (= half-life)
pH:
9
Temp.:
25 °C
DT50:
> 1 yr
Type:
(pseudo-)first order (= half-life)
Details on results:
The test substance has a half-life time longer than one year at 25 °C at pH 4, 7 and 9.
Validity criteria fulfilled:
yes
Conclusions:
FAT 45155/B has a half-life time longer than one year at 25 °C at pH 4, 7 and 9 and the test substance is considered stable.
Executive summary:

A GLP-compliant hydrolysis test was performed with FAT 45155/B according to the OECD guideline 111 to evaluate the hydrolysis of test substance as a function of pH. The test substance was dissolved in aqueous buffer solution, and the temperature and pH were checked at pH 4, 7 and 9 respectively. The decrease of the concentration with time was determined by HPLC. The test results showed that the test substance has a half-life time longer than one year at 25 °C at pH 4, 7 and 9. The test substance is stable at pH 4, 7 and 9.

Description of key information

The test substance has a half-life time longer than one year at 25 °C at pH 4, 7 and 9 and is stable at pH 4, 7 and 9.

Key value for chemical safety assessment

Half-life for hydrolysis:
1 yr
at the temperature of:
25 °C

Additional information

A GLP-compliant hydrolysis test was performed with FAT 45155/B according to the OECD guideline 111 to evaluate the hydrolysis of test substance as a function of pH. The test substance was dissolved in aqueous buffer solution, and the temperature and pH were checked at pH 4, 7 and 9, respectively. The decrease of the concentration with time was determined by HPLC. The test results showed that the test substance has a half-life time longer than one year at 25 °C at pH 4, 7 and 9. The test substance is stable at pH 4, 7 and 9.