Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 206-991-8 | CAS number: 409-21-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- other: epidemiological study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
Data source
Materials and methods
- Study type:
- other: cohort study (retrospective)
- Endpoint addressed:
- repeated dose toxicity: inhalation
- carcinogenicity
Method
- Details on study design:
- The study was of a cohort design with a comparison of the cancer morbidity and mortality with that of the general population. Complete personnel files were available from about 1955. These files were used to identify a cohort of men with at least five years employment some time between 1955 and 1983. A total of 911 individuals were enrolled; 211 were women, both in administration and production, and of the 700 men, 521 were blue collar workers. All individuals were traced through the official registers and followed up until 31 December 1983 if not dead or emigrated before that date. Seven men had emigrated and eight could not be traced; all were blue collar workers. The loss to follow up was thus about 2% in total or 3% for the blue collar workers.
Information about mortality and cancer morbidity was collected through the National Death Register and the National Cancer Register, respectively. Only the underlying cause of death was considered and a restriction was made by excluding ages above 74 as the diagnostic validity is likely to decrease at higher ages. The observation periods were 1958-83 for mortality and 1958-81 for cancer morbidity, the reason for the difference in the observation period being the lack of cancer incidence data after 1981. Expected incidences were calculated with the person-year method using incidence rates for the general population, stratified for age, calendar year, and gender, for which procedure the EPILIN program was used.
Results and discussion
Any other information on results incl. tables
No significant increase was found in mortality or in cancer morbidity among the blue collar workers.
Among the blue collar workers were four cases of non-malignant respiratory diseases (pneumonia (1), chronic bronchitis (2), and asthma (1)), whereas 3.2 cases of respiratory diseases would have been expected for the general population.
No case of silicosis was found.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.