Registration Dossier
Registration Dossier
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EC number: 235-186-4 | CAS number: 12125-02-9
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- not specified
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Limited information about the test substance, animals, conditions.
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Warren, K.S.,
- Year:
- 1 957
- Bibliographic source:
- Journal of Clinical Investigation, 37, 497-501(1957)
Materials and methods
Test guideline
- Guideline:
- other: not mentioned
- Principles of method if other than guideline:
- Method followed unknown
- GLP compliance:
- no
Test material
- Reference substance name:
- Ammonium chloride
- EC Number:
- 235-186-4
- EC Name:
- Ammonium chloride
- Cas Number:
- 12125-02-9
- Molecular formula:
- ClH4N
- IUPAC Name:
- ammonium chloride
- Details on test material:
- Reagent grade, purity: unknown
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- water
- Details on exposure:
- Mice were injected one ml of isotonic saline containing the ammonium chloride (three to five concentration levels) into tail vain.
- Doses:
- one ml of isotonic saline containing the ammonium chloride (three to five concentration levels)
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 353 mg/kg bw
- Mortality:
- no data
- Clinical signs:
- no data
- Body weight:
- no data
- Gross pathology:
- no data
- Other findings:
- no data
Any other information on results incl. tables
no remarks
Applicant's summary and conclusion
- Conclusions:
- LC50 (mice, intravenous administration) = 353 mg/kg bw.
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