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Diss Factsheets
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EC number: 215-100-1 | CAS number: 1302-42-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional information on environmental fate and behaviour
Administrative data
- Endpoint:
- additional information on environmental fate and behaviour
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- n/a
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: CANMET and LISEC (2004) The Standard Operating Procedure for the Transformation/Dissolution of Metals and Sparingly Soluble Metal Compounds, Version February 2004
- Qualifier:
- according to guideline
- Guideline:
- other: OECD (2001) Series on testing and assessment number 29. Guidance document on transformation/dissolution of metals and metal compounds in aqueous media
- Principles of method if other than guideline:
- The transformation / dissolution of aluminium compounds were tested in accordance to the draft OECD Transformation/Dissolution protocol. The experimental design includes refinements, agreed by the ad hoc OECD Validation Management Group (VMG), as described in the Standard Operating Procedures prepared by CANMET and LISEC. Samples of a commercially available Aluminium Hydroxide were tested at 1 and 100 mg/L loadings at pH 6 and 8, for up to 28 days at a stirring rate of 100 rpm. The results can be used to compare with existing ecotoxicity data and to establish the hazard classification of the tested substance.
- GLP compliance:
- not specified
- Type of study / information:
- Transformation / dissolution study
Test material
- Reference substance name:
- Aluminium hydroxide
- EC Number:
- 244-492-7
- EC Name:
- Aluminium hydroxide
- Cas Number:
- 21645-51-2
- Molecular formula:
- AlH3O3
- IUPAC Name:
- aluminum trihydroxide
- Details on test material:
- - Name of test material (as cited in study report): Aluminiumhydroxid (dry), Al(OH)3/SH-20 Muster from AOS Aluminiumoxid Stade, Germany
- Analytical purity: pure
- Composition of test material, percentage of components: 65.1 ± 0.3% (dry weight as Al2O3)
- Purity test date: 01.06.2006
-Particle distribution ( <45µm): 2.8±1% (ISO 13320-1)
Constituent 1
Results and discussion
Any other information on results incl. tables
Preliminary assay:
Since dissolved aluminium is prone to suffer changes in solubility with time, a preliminary experiment was set up to determine the effect of the sitting time after the sample is taken from the Dissolution /Transformation (D/T) test and the amount of dissolved metal in solution. 100 mg/L of Al2O3 were subject to 24h D/T test, pH 6 and 8 at 100 RPM. After the 24h a total of 30 samples of 10 mL per pH were taken from the vessel, filtered and acidified. The samples were let to sit for aluminiun determination for 0, 8, 24, 48 and 72 hour.
At both pHs the amount of dissolved aluminium remains constant after the 8 hours sitting period. Therefore, in Dissolution /Transformation study all the samples were measure in a period of 24 to 48 hours after the samples were taken from the test.
Temperature, Oxygen and pH control:
The temperature of the test media varied between 18.8 and 24 °C. The O2 concentrations of the test media varied between 7.19 and 8.37 mg O2/L. The pH of the media varied between 6.04 and 6.35 (pH 6 media) and 7.63 and 8.07 (pH 8 media), temperature between 20 & 25 °C, dissolved oxygen concentration above 70% of its saturation in air and pH around 0.2 units difference from the desired pH.
Dissolution Transformation Results:
Aluminium Hydroxide was submitted to dissolution/transformation test at pHs 6 and 8 at two loadings, 1 mg/L for 28 days and 100 mg/L for 7 days. At pH 6 Aluminium Hydroxide, in all tested condition, showed very low release of dissolved metal (see table 1). The amounts of metal released by the samples and the blanks were undistinguishable. The same was found for Aluminium hydroxide at pH 8.0, at high and low loading, where the amounts of metal released by the samples were at blanks levels.
Table 1: Summary of the short term (7 days) and long term (28 days) transformation/dissolution data obtained for Al(OH)3, at different loadings and pHs. Blank values are included but not subtracted.
Loading |
pH |
Endpoint |
Al, µg/L |
St. Des. |
CV, % |
Blanks |
6 |
7 days |
2 |
0.00 |
0 |
1 mg/L |
6 |
7 days |
3 |
1.86 |
72 |
1 mg/L |
6 |
28 days |
4 |
2.07 |
55 |
100 mg/L |
6 |
7 days |
2 |
1.67 |
79 |
Blanks |
8 |
7 days |
3 |
0.00 |
0 |
1 mg/L |
8 |
7 days |
3 |
0.49 |
15 |
1 mg/L |
8 |
28 days |
3 |
0.00 |
0 |
100 mg/L |
8 |
7 days |
4 |
1.39 |
40 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.