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EC number: 257-098-5 | CAS number: 51274-00-1 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77492.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: as reported in source record
- Justification for type of information:
- see "Endpoint-specific read-across justification for nanoforms of iron oxide_2021” and "Read-across justification-environ assessment-iron oxides_2021” attached in IUCLID section 13
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 20 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other: as reported in source record
Reference
Description of key information
Applying read-across (category approach) to diiron trioxide in nanoform (see attachment "Iron oxides category justification” in IUCLID section 13), iron hydroxide oxide yellow in nano-form (alpha) is considered not chronically toxic to aquatic invertebrates. No effects of Fe2O3 nanoparticles on the reproduction of Daphnia magna were observed in a reliable 21 -d chronic toxicity study according to OECD 211 up to the highest test concentration of 20 mg Fe2O3/L (Nogueira et al., 2015).
Key value for chemical safety assessment
Additional information
A chronic toxicity study was performed by Nogueira et al. (2005) according to OECD 211 to assess the potential effects of nano-Fe2O3 (average particle size 85 × 425 nm) at concentrations of up to 20 mg/L on the reproduction of Daphnia magna, a concentrationthat is 2-fold above the corresponding OECD test limit for chronic toxicity. A significant effect on the reproduction (number of offspring) of Daphnia magna was not observed for Fe2O3 nanoparticles at the applied concentrations of 8.2 to 20.0 mg/L and thus an unbounded 21 d NOEC >= 20 mg/L (nominal) was derived.
Based on read-across to nanosized iron (hydr)oxides (see attachment "Read-across justification-environ assessment-iron oxides" and “Endpoint-specific read-across justification for nano forms of iron oxide, 2021” attached in IUCLID section 13), available data indicate a low potential for chronic toxicity ofnanosized iron manganese trioxideto aquatic invertebrates (see table below).
Table: Chronic toxicity of nanosized iron (hydr)oxides to aquatic invertebrates.
Endpoint |
Test species |
Test results |
Test material/form |
Reliability: Reference |
Long-term toxicity to aquatic invertebrates |
Daphnia magna |
NOEC (21d): >= 20 mg/L nominal |
diiron trioxide / nano |
RL2: Nogueira et al., 2015 |
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