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Diss Factsheets
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EC number: 424-450-6 | CAS number: 152628-03-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG, B.3; OECD 402
- GLP compliance:
- yes
- Limit test:
- yes
Test animals
- Species:
- other: rat, Wistar Crl:(WI)BR
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: Propylenglykol
- Duration of exposure:
- 24 h
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: Es traten keine Todesfälle auf. Die Körpergewichtszunahme während der Nachbeobachtungszeit bewegte sich in dem Rahmen, der für Ratten, die für diese Art von Studien eingesetzt werden, erwartet wird. "ENGLIS
- Gross pathology:
- Effects on organs:
Bei der makroskopischen Untersuchung der Tiere wurden keine
Abnormalitäten gefunden.
"ENGLISH"
Macroscopic investigation of the animals did not reveal any
abnormalities. - Other findings:
- Signs of toxicity (local):
Bei den Tieren wurden Hautrötungen, Schuppen- und
Schorfbildung im Rückenbereich und rote Flecken auf der
Nase, im periorbitalen Bereich, im Nacken und auf dem Rücken
beobachtet. Die Tiere erholten sich von den Symptomen
zwischen dem 3. und 9. Tag, ausgenommen ein weibliches Tier,
bei dem die roten Flecken im Rücken- und Nackenbereich bis
zum Ende der Beobachtungszeit andauerten.
"ENGLISH"
The animals exhibited skin redness, the formation of scales
and eschar in the back region and red patches on the nose,
in the periorbital area, on the back of the neck and on
the back. With the exception of one female animal in which
the red patches in the region of the back and the back of
the neck persisted until the end of the observation period,
the animals recovered from the symptoms between the 3rd
and the 9th day.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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