Registration Dossier
Registration Dossier
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EC number: 200-877-1 | CAS number: 75-54-7
Endpoint summary
Administrative data
Description of key information
The key oral LD50 value (0.28 mg/kg based on density of 1.105) is derived from a gavage study (BRRC, 1981) in Wistar rats comparable to the now deleted OECD 401. Sluggishness was the main clinical sign of toxicty, but there were also some instances of dyspnea, unsteady gait and prostration. Gross necropsy mainly revealed discoloured, fluid-filled and/or enlarged organs (liver, spleen, intestines, stomach, kidneys). The key inhalation LD50 value is derived from a whole body one-hour vapour inhalation study (DCC, 2001) in Fischer 344 rats comparable to OECD 403. The principal clinical signs were indicative of respiratory and ocular effects: labored breathing, gasping and rales, ocular opacity that progressed to more severe ocular damage well into the observation period, salivation, green staining of various body surfaces, dried material around the eyes nose and/or mouth, lacrimation, hypoactivity, red and swollen paws and nasal discharge. The most common necropsy finding in this study was ocular damage. There are no acute dermal data.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 280 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 8 397.9 mg/m³ air
Additional information
In the case of the inhalation route, there are two reliability score 1 studies; the most recent of these was selected as the key study. The second study supports the LD50 obtained in the key study.
Justification for classification or non-classification
This substance is labelled as 'R22 Harmful if swallowed' according to Directive 67/548/EEC, and the proposed hazard class under Regulation 1272/2008 is 'Acute toxic 3 (oral)' based on an acute oral LD50 of 280 mg/kg (0.25 ml/kg).
In the case of dermal toxicity, there are no existing classification, and there is no evidence to suggest that dichloro(methyl)silane should be classified for acute systemic toxicity.
Labelling for the inhalation route is 'R20 Harmful by inhalation' according to Directive 67/548/EEC, and the proposed hazard class under Regulation 1272/2008 is 'Acute toxic 3 (vapour)', as the LD50 is in the range 2.0 to 10.0 mg/l.
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