Registration Dossier
Registration Dossier
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EC number: 266-113-4 | CAS number: 66071-94-1 Substance obtained by the partial removal of water from the liquid resulting from steeping corn in a water and sulphur dioxide solution which is allowed to ferment by the action of naturally occurring lactic acid-producing microorganisms.
Endpoint summary
Administrative data
Description of key information
Skin irritation study on Corn Steep Liquor in rabbit have demonstrated that the test compound is not a skin irritant.
Eye irritation study on Corn Steep Liquor in rabbit have demonstrated that the test compound is not an eye irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The skin irritation potential of CSL was assessed in rabbits in a GLP-compliant study performed according to OECD Guidelines for the Testing of Chemicals No. 404. In this study, New Zealand White rabbits were exposed to 0.5 mL of undiluted CSL under semi-occlusive conditions. One hour after removal of the dressing, 2/3 animals presented a slight erythema (score 1) after the 4 hours exposure time. This erythema persisted up to time 72 hours for the first animal and up to time 24 hours for one other animal. No cutaneous lesion persisted on day 8 or at time 72 hours.
The eye irritation potential of CSL was assessed in rabbits in a GLP-compliant study performed according to OECD Guidelines for the Testing of Chemicals No. 405. In this study, 0.1 mL of undiluted CSL was instilled into the eye lids of each of New Zealand White rabbits. Ocular changes were assessed and recorded immediately at 1, 24, 48, and 72 hours after treatment. Scoring was performed according to guideline methods. One hour after instillation, all animals had lacrimation, chemosis and redness. 24 hours after instillation, all animals had still lacrimation, chemosis and redness. From time 48 hours, ocular lesions decrease because all animals had lacrimation, redness and only one animal had chemosis. No ocular lesion was persisted on day 8.
Justification for classification or non-classification
The substance does not meet the criteria for classification and labelling for this endpoint, as set out in Regulation (EC) NO. 1272/2008.
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