Registration Dossier
Registration Dossier
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EC number: 204-781-0 | CAS number: 126-30-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature; no further details available than those documented below (e.g. no details about test substance, no data about number of animals or post exposure observation period).
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Information profiles on potential occupational Hazards: Glycols
- Author:
- NIOSH
- Year:
- 1 982
- Bibliographic source:
- PB 89-215776
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Limit test comparable to OECD Guideline 402 but occlusive dressing (worst case scenario).
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,2-dimethylpropane-1,3-diol
- EC Number:
- 204-781-0
- EC Name:
- 2,2-dimethylpropane-1,3-diol
- Cas Number:
- 126-30-7
- Molecular formula:
- C5H12O2
- IUPAC Name:
- 2,2-dimethylpropane-1,3-diol
- Details on test material:
- 2,2-Dimethyl-1,3-propanediol
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no details
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: acetone-cornoil mixture
- Details on dermal exposure:
- 20% solution in vehicle
- Duration of exposure:
- 24 h
- Doses:
- 4000 mg/kg bw
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- depilated skin of guinea pigs; impervious coverage; no further details
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 4 000 mg/kg bw
- Remarks on result:
- other: Limit test
- Mortality:
- no mortality
- Clinical signs:
- other: Only slightly to moderately irritating; no evidence for systemic toxicicity; skin absorption is not excluded comparing with effective dose levels in acute oral toxicity (see Section 7.2.1).
- Gross pathology:
- no data
- Other findings:
- no
Applicant's summary and conclusion
- Conclusions:
- No mortality in guinea pigs after occlusive dermal exposure for 24 h to 4000 mg/kg bw.
- Executive summary:
The data are from secondary literature; no further details available than those documented above (e.g. no details about test substance, no data about number of animals or post exposure observation period).
Guinea pigs were dermally exposed to 4000 mg/kg bw for 24 h. An occlusive coverage was used. No mortality was found; no systemic toxicity was detected. Only slightly to moderately irritating effects were reported. But skin absorption is not excluded from these results comparing with effective dose levels in acute oral toxicity.
Conclusion: No mortality in guinea pigs after occlusive dermal exposure for 24 h to 4000 mg/kg bw.
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