Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 914-100-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Potassic extracts are a multiconstituent substance composed of simple inorganic salts (i.e. potassium sulfate, sodium sulfate and calcium sulfate). In aqueous environment, the soluble portion of each constituent completely dissociates into the sulfate ion (SO42 -) and the corresponding cations : potassium (K+), sodium (Na+) and calcium (Ca2 +) at neutral pH. Sulfate is a normal constituent of the blood and is a normal metabolite of sulfur-containing amino acids. Sulfate does not accumulate in tissues and is usually eliminated by renal excretion. It has also an important role in the detoxification of various endogenous and exogenous compounds, as it may combine with these to form soluble sulfate esters that are excreted in the urine. In humans, absorption of small amounts of sulfate from the gut occurs rapidly and almost completely. In a study with 8 volunteers, small amounts (60 -80 µCi) of radioactive sulfate-35 were administered orally or intravenously. Plasma equilibrium was reached within 60 to 105 and 60 to 90 minutes respectively, and in both cases 80 % or more of the administered amount of radioactivity was recovered in the urine within 24 hours (Bauer et al., 1976). After absorption free sulfate ions rapidly distribute over the extracellular space, the apparent volume of distribution being around 20 % of the body volume. The serum concentration of sulfate in humans ranges between 1.4 and 4.8 mg/100 ml, with a mean of about 3.1 mg/100 ml. Excretion is mainly in urine. The renal clearance is approximately one third of the glomerular filtration rate, indication tubular re-absorption. However, the total free sulfate excretion rate is not dependent on urine flow rate. Organically bound sulfate may follow different excretion patterns (Cochetto and Levi, 1981).
Conclusion: Sulfate (and sodium, calcium, potassium) ions are important constituents of the mammalian body and of natural foodstuffs and there is a considerably daily turnover of these ions. Near-complete absorption of diatery sulfates may occur at low concentration, depending on the counter-ion, but absorption capacity can be saturated at higher artificial dosages. At diatery levels, excretion is mainly in the urine. Sulfates are found in all body cells, with highest concentrations in connective tissues, bone and cartilage. Sulfates play a role in several important metabolic pathways, including those involved in detoxification processes. Based on low MW, high water solubility, assumed low logPow high absorption is expected. However, the ion formation of the substance immediately after contact wirh a fluid decreases the absorption. Taken into consideration the guidance, 50 % absorption for oral, dermal and inhalation exposure has been retained.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.