Registration Dossier
Registration Dossier
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EC number: 200-663-8 | CAS number: 67-66-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Limited information available
Data source
Reference
- Reference Type:
- publication
- Title:
- The toxicity of chloroform as determined by single and repeated exposure of laboratory animals
- Author:
- Torkelson TR, Oyen F, Rowe VK
- Year:
- 1 976
- Bibliographic source:
- Am. Ind. Hyg. Ass. J. 37(12), 697-705
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A single dose of chloroform was applied to the skin of healthy rabbits and kept occluded for 24 hours.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Chloroform
- EC Number:
- 200-663-8
- EC Name:
- Chloroform
- Cas Number:
- 67-66-3
- Molecular formula:
- CHCl3
- IUPAC Name:
- trichloromethane
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- 24 hours
- Doses:
- 1.0, 2.0 or 3.98 g chloroform/kg body weight
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 3 980 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- In the test, chloroform was not acutely toxic to the rabbit via the skin.
- Executive summary:
Single application of either 1.0, 2.0 or 3.98 g chloroform/kg body weight for 24 hours under an impermeable plastic cuff held tightly around the clipped bellies of each of two rabbits did not result in any deaths.
The dermal LD50 value of chloroform thus can be considered to be greater than 3.98 g/kg body weight in the rabbit.
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