2,4,6-trichloro-1,3,5-triazine

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

other: report on accidential exposure

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: - Documentation insufficient for assessment

Data source

Reference

Reference Type:

publication

Title:

SU DI UN CASO DI INTOSSIGAZIONE ACUTA PROFESSIONALE DA 2-4-6 TRICLORO-1-TRIAZINA (CLORURO DI CIANURILE)

Author:

Catenacci, G

Year:

1987

Bibliographic source:

Le medicina del lacoro, 1987,78:2; 155-161

Materials and methods

Study type:

poisoning incident

Endpoint addressed:

acute toxicity: inhalation

acute toxicity: dermal

eye irritation

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2,4,6-trichloro-1,3,5-triazine

EC Number:

203-614-9

EC Name:

2,4,6-trichloro-1,3,5-triazine

Cas Number:

108-77-0

Molecular formula:

C3Cl3N3

IUPAC Name:

trichloro-1,3,5-triazine

Method

Type of population:

occupational

Subjects:

- Number of subjects exposed: 1
- Sex: male
- Age: 54
- Race: caucassian
- Demographic information: not applicable
- Known diseases: generally healthy

Ethical approval:

not specified

Route of exposure:

dermal

inhalation

ocular

Reason of exposure:

accidental

Exposure assessment:

not specified

Details on exposure:

Cyanuric chloride (one of the basic materials) was accidentally released, because a vessel got broken. The man was totally submerged under the powder.

Examinations:

- ECG 1 day and 10 days post exposure
- Urine analysis: not reported
- Haematology: yes, but not described in detail
- Lung function parameters: respirometry (6 times within 4 weeks after the exposure and once 6 months after exposure), oxygen and carbon dioxide concentrations in the blood, blood pH (8 times within 4 weeks after the exposure and once 6 months after exposure)
- analysis of skin and conjunctiva
- auscultation of the lungs and hearts
- palpitation of abdomen, thorax and lymph nodes

Medical treatment:

- rinsing of the eyes with physiological solution, further not specified treatment of the eyes
- administration of oxygen in the first night after exposure
- treatment with antibiotics and corticoids, mucolytics and teofilin

Results and discussion

Clinical signs:

Signs of intoxication consisted of irritation of the skin, eyes and pharynx, followed by serious obstructive pulmonary syndrome with impairment of alveolar capillary exchanges. No effects on the heart function was seen (although a slightly abnormal ECG was reported from an pre-exposure investigation).

Results of examinations:

- Urine analysis: not reported
- Haematology: leucocytosis (neutrophils), one day post exposure
- Lung function parameters: marked reduction of the vital capacity until 11 days post exposure, reduction of blood oxygen concentration and rise of carbon dioxide concentration until 7 days after exposure, no effects on blood pH.
- slightly abnormal respiratory sounds in the first time after exposure, viscous mucous in the respiratory tract.

Outcome of incidence:

The man recovered within 20 days.

Applicant's summary and conclusion

Conclusions:

The author reported the occures of irritation to the skin, eyes and pharynx followed later by a serious obstructive pulmonary syndrome with impairment of alveolar-capillary exchanges in case of acute occupational intoxication that occured accidentally in a plant producing herbicides. The patient fully recovered from the skin, eye and lung disorders in three weeks. Due to the insufficient documentation an assessment of the results is not possible.