Registration Dossier
Registration Dossier
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EC number: 617-969-6 | CAS number: 87135-01-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
In a combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test conducted to OECD 422 (oral route) and to GLP (Dow Corning, 2010) at doses of 0, 30, 300 and 1000 mg/kg/day there were no effects of treatment on reproductive parameters. The No-Observed-Adverse-Effect-Level (NOAEL) for reproductive toxicity was therefore identified as ≥1000 mg/kg/day
Short description of key information:
There is a reliable OECD 422 screening study available for 1,6-bis(trimethoxysilyl)hexane. There are no other studies relating to reproductive toxicity. In the toxicity assessment part of the study the reproductive organs were weighed and were the subject of histopathological examinations, and there were no adverse findings.
Justification for selection of Effect on fertility via oral route:
The selected study is the only study available for reproductive toxicity. It was conducted in accordance with an appropriate OECD test guideline and in compliance with GLP.
Effects on developmental toxicity
Description of key information
There is a reliable OECD 422 screening study available for 1,6-bis(trimethoxysilyl)hexane. There are no other studies relating to developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
In a combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test conducted to OECD 422 (oral route) and to GLP (Dow Corning 2010) at doses of 0, 30, 300 and 1000 mg/kg/day there were no effects of treatment on developmental parameters. The No-Observed-Adverse-Effect-Level (NOAEL) for developmental toxicity was therefore identified as ≥1000 mg/kg/day
Justification for selection of Effect on developmental toxicity: via oral route:
The selected study is the only study available for developmental toxicity. It was conducted in accordance with an appropriate OECD test guideline and in compliance with GLP.
Justification for classification or non-classification
Based on the available OECD 422 screening study 1,6 -bis(trimethoxysilyl)hexane is not classified for effects on reproduction or development according to Regulation (EC) No 1272/2008.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
