Registration Dossier

Administrative data

Endpoint:
bioaccumulation: aquatic / sediment
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Study period:
2009
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Accepted estimation technique.

Data source

Reference
Reference Type:
publication
Title:
Environmental Risk Evaluation Report: Long-Chain Chlorinated Paraffins.
Author:
UK Environment Agency
Year:
2009
Bibliographic source:
UK Environment Agency
Report Date:
2009

Materials and methods

Principles of method if other than guideline:
Estimate, TGD Section 3.8.3.2. According to the TGD, the bioconcentration factor (BCF) for fish can be estimated from the following equation.
log BCF = -0.20×(log Kow)2 + 2.74×log Kow - 4.72
where log Kow = 9.7
The equation applies to substances with log Kow >6 and molecular weights <700g/mole.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Radiolabelling:
no

Test solutions

Vehicle:
no

Test organisms

Test organisms (species):
other: model results

Study design

Route of exposure:
other: model results
Test type:
other: model results

Results and discussion

Bioaccumulation factoropen allclose all
Type:
BCF
Value:
1 096 L/kg
Basis:
other: model result
Calculation basis:
steady state
Remarks on result:
other: C18-C20 liquid
Type:
BCF
Value:
192 L/kg
Basis:
other: model result
Calculation basis:
steady state
Remarks on result:
other: C20-C30 liquid LCCP
Type:
BCF
Value:
< 1 L/kg
Basis:
other: model result
Calculation basis:
steady state
Remarks on result:
other: C20-C30 solid

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
 C18‑20liquid LCCP    BCF = 1,096 L/kg
  C20-30liquid LCCP    BCF = 192 L/kg
  C20-30solid LCCP      BCF <1 L/kg
Executive summary:

The potential for uptake and accumulation of the substance by fish and other aquatic and terrestrial organisms is uncertain, but appears to decrease with increasing carbon chain length and increasing degree of chlorination. The model estimated BCFs in fish for the LCCP are as follows (method taken from the EU Technical Guidance Document parabolic equation, application for substances with log Kow >6 and molecular weight < 700 g/mol: log BCF = -0.2 x(log Kow)2+ (2.74 x log Kow – 4.72); (Veith et al, 1979):

 

                       C18‑20liquid LCCP    BCF = 1,096 L/kg

                       C20-30liquid LCCP    BCF = 192 L/kg

                       C20-30solid LCCP      BCF <1 L/kg

 

There is evidence from feeding studies that LCCPs can be taken up via the diet, but in all cases the concentrations reached in the animals were less than those in the diet. This indicates that although uptake of the substance can occur via the food, the levels should not increase through the food chain (UK EA 2009).

 

Based on the estimates of BCF and taking the known accumulation properties of structurally similar substances (SCCPs and MCCPs) into account, the BCF for LCCPs is considered to be <2,000 L/kg (UK EA, 2009). Thus it is concluded that LCCPs are unlikely to meet the B or vB (very bioaccumulative) EU criteria.