Registration Dossier
Registration Dossier
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EC number: 203-550-1 | CAS number: 108-10-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1951
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The work of this group pre-dates range finding toxicity guidelines and provided much of the basis for their development. Their results are cited by many subsequent authoritative review bodies and are often found in SIDS and SIAR documents via secondary references. Therefore, these results are deemed reliable.
Data source
Reference
- Reference Type:
- publication
- Title:
- RANGE-FINDING TOXICITY DATA: LIST IV
- Author:
- Smyth HF, Carpenter CP & Weil CS
- Year:
- 1 951
- Bibliographic source:
- AMA Arch Ind Hyg Occup Med, 4, 119-122
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Insufficient reporting of methodology and individual results
- GLP compliance:
- no
- Remarks:
- study pre-dates GLP requirements
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-methylpentan-2-one
- EC Number:
- 203-550-1
- EC Name:
- 4-methylpentan-2-one
- Cas Number:
- 108-10-1
- Molecular formula:
- C6H12O
- IUPAC Name:
- 4-methylpentan-2-one
- Details on test material:
- Name of test material (as cited in study report): 4-methyl-2-pentanone
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- No data
- Doses:
- Not reported
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- No data
- Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2.08 other: g/kg body weight
- 95% CL:
- 1.91 - 2.27
- Mortality:
- No data
- Clinical signs:
- other: No data
- Gross pathology:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- CLP (EC 1272/2008)
- Executive summary:
The rat oral LD50 was 2080 mg/kg bw when MIBK was administered as a 20% emulsion in Terginol 7 surfactant. The study used six animals per group. Additional details of the study were not included in the publication.
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