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EC number: 220-767-7 | CAS number: 2893-78-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jan 5 1995 - Jan 26 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed to GLP and guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-4 (Acute Eye Irritation)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Troclosene sodium
- EC Number:
- 220-767-7
- EC Name:
- Troclosene sodium
- Cas Number:
- 2893-78-9
- Molecular formula:
- C3HCl2N3O3.Na
- IUPAC Name:
- sodium 3,5-dichloro-2,4,6-trioxo-1,3,5-triazinan-1-ide
- Details on test material:
- - Name of test material (as cited in study report): ACL 60
- Physical state: White granular powder
- Analytical purity: Sodium dichloroisocyanurate - 96.0-98.0%, sodium chloride -0.1%, water 0.5%
- Lot/batch No.: #LBO4-2118
- Stability under test conditions: Stable provided material is kept dry
- Storage condition of test material: Stored at room temperature
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: New Zealand Albino
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Davidsons Mill Farm, South Brunswick, NJ
- Age at study initiation: Adult
- Housing: Suspended stainless steel caging with mesh floors
- Diet: Pelleted Purina Rabbit Chow #5326
- Water: ad libitum
- Acclimation period: 22 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 69-76
- Photoperiod (hrs dark / hrs light): 12 hour light/12 hour dark
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.1 g - Observation period (in vivo):
- Irritation was observed at 1, 24, 48 and 72 hours and 4, 7, 10, 14, 17 and 21 days post-instillation
- Number of animals or in vitro replicates:
- 6 (3/sex)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: The eyes of all animals were washed with 30ml of physiological saline 20-30 seconds after instillation.
SCORING SYSTEM: Draize
TOOL USED TO ASSESS SCORE: Occular irritation was evaluated using a high-intensity white light (Mag Lite). The fluorescein dye procedure was used at 24 hours and at all subsequent scoring intervals to evaluate the extent of corneal damage.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Remarks:
- opacity
- Basis:
- mean
- Remarks:
- animal 1 and 2
- Time point:
- other: 24, 48, 72 h
- Score:
- 1
- Irritation parameter:
- cornea opacity score
- Remarks:
- opacity
- Basis:
- mean
- Remarks:
- animal 3
- Time point:
- other: 24, 48, 72 h
- Score:
- 1.33
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- animal 1, 2 and 3
- Time point:
- other: 24, 48, 72 h
- Score:
- 1
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Remarks:
- animal 1,2 and 3
- Time point:
- other: 24, 48, 72 h
- Score:
- 2.67
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- animal 1 and 3
- Time point:
- other: 24, 48, 72 h
- Score:
- 2
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- animal 2
- Time point:
- other: 24, 48, 72 h
- Score:
- 3
- Irritant / corrosive response data:
- Severe irritation including corneal opacity, iritis and conjunctivitis was noted in all treated eyes throughout the study. Pannus was also noted in five of six animals between days 7 and 21. A hematoma was evident on the cornea of two animals on day 10 of the study and two rabbits exhibited a slight green dicolouration of the conjunctival tissue. Although by day 21, conjunctivitis and iritis cleared from one and two eyes respectively, ocular irritation persisted in all animals through study termination.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Sodium dichloroisocyanurate is corrosive to eyes due to the persistance of irritation which was not fully reversible within the observation period of 21 days
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