Registration Dossier
Registration Dossier
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EC number: 203-561-1 | CAS number: 108-21-4
Endpoint summary
Administrative data
Description of key information
Additional information
Results from static studies in two species are available. These are consistent with each other. The key value chosen is the lowest value available. There is no data from saltwater species available.
Reliable studies are available for toxicity in invertebrates. A study using the saltwater species Artemia salina resulted in an EC50 value of 110mg/l. This was substantially lower than the 24hr interim EC50 of 810mg/l. In three other studies, 24hr values are available for D magna of 1260 and 4150mg/l and a 48hr LC50 of >1000mg/l.
No reliable algal toxicity studies have been identified for isopropyl acetate. Reliable studies are available for members of the alkyl acetate family either side of isopropyl acetate in the homologous series. QSAR modelling suggests that the toxicity of isopropyl acetate will be more than ethyl acetate but less than butyl acetate. On this basis, the available data for butyl acetate is used as a conservative basis to derive the key parameter for this end point.
Bringmann and Kuehn reported toxicity threshold results for isopropyl acetate in micro-organisms for four species across a number of publications. This data is considered sufficient using a weight of evidence approach to conclude that this substance has low toxicity to waste water treatment plants. The lowest value is selected for the key parameter. This also happens to be based on an appropriate species. There is also reliable supportive information available from a limit test using sludge respiration inhibition as the end point.
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