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EC number: 231-151-2 | CAS number: 7440-42-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004-01-12 to 2004-01-28
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study reliable without restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- adopted 2001-12-17
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Boron
- EC Number:
- 231-151-2
- EC Name:
- Boron
- Cas Number:
- 7440-42-8
- Molecular formula:
- B
- IUPAC Name:
- borane
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Bor kristallin
- Physical state: grey to black, odourless powder
- Storage condition of test material: room temperature, closed original container, dry
- Water solubility: < 1mg/L
- pH: 7 (suspension in water [100 g/L])
- Particle size distribution: D90 = 33.06 µm; D50 = 13.76 µm; D10 = 2.34 µm
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS - SPF rats
- Source: Firma Charles River Wiga GmbH, D-97320 Sulzfeld
- Age at study initiation: ca. 8 weeks
- Weight at study initiation (before application of test substance): mean body weight (n = 6): 195.0 g ± 8.4 g
- Fasting period before study: the night before the application of the test material and 3 hours following the application of the test material
- Housing: during the acclimation period the animals were housed in groups of up to three animals in Makrolon type 3 cages. From the moment of randomisation up to the end of the observation period the animals were housed individually in Makrolon Type 3 cages. ALTROMIN TYP S8/15 (laboratory animal bedding material, soft wood granulates, charge: 071103 and 080104 (from 23.01.2004)) was used as bedding material.
- Diet (ad libitum): ALTROMIN 1324, standard diet, maintenance diet rats/mice (Firma ALTROMIN, D-32791 Lage/Lippe; charge: 220204/1144)
- Water (ad libitum): tap water, drinking water quality, changed daily
- Acclimation period: 7 and 8 days, respectively
ENVIRONMENTAL CONDITIONS
- Temperature: 20.5 - 21.5 °C
- Relative humidity: 30 - 45%
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5% Tylose solution in demineralised water
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 1/100 g bw
DOSAGE PREPARATION:
The test material was suspended in a 0.5% tylose solution in demineralised water. During the application procedure the suspension was stirred to ensure a homogenous distribution.
(3 g test material with 15 mL 0.5% tylose solution in demineralised water) - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 6 female rats
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: the animals were observed for mortality/morbidity continuously on the day of test item application and at least once daily thereafter (morning). The animals were observed for clinical signs continuously on the day of test item application and once daily thereafter (morning). The body weight of the animals was determined on the day before the application of the test material and on the day of application as well as on day 7 and 14 after application.
- Necropsy of survivors performed: yes; at the end of the observation period all animals were killed and macroscopically examined (body surface, skull, chest cavity and abdominal cavity and including the respective organs) - Statistics:
- Body weight and body weight increase: calculation of mean body weight and standard deviation and comparison with historical control data
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred during the study.
- Clinical signs:
- other: No clinical signs were observed during the study.
- Gross pathology:
- No macroscopical findings were made.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 (female rat) > 2000 mg/kg bw (LD50 cut-off value: 5000 mg/kg bw)
According to the EC-Commission directive 67/548/EEC and its subsequent amendments, the test substance is not classified as acute toxic via the oral route.
According to the EC-Regulation 1272/2008 and subsequent regulations, the test item is not classified as acute toxic via the oral route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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