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Diss Factsheets
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EC number: 201-236-9 | CAS number: 79-94-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP data; methodology predates or was not conducted according to standardized guidelines; no analytical verification of test compound concentrations
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Wistar rats, NDMI mice, and guinea pigs were exposed to aersolised tetrabromobisphenol-A for eight hours, followed by a 48 hour observation period and necropsy.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Details on test material:
- - Name of test material (as cited in study report): Tetrabromobisphenol-A
- Molecular formula (if other than submission substance): N/A
- Molecular weight (if other than submission substance):N/A
- Smiles notation (if other than submission substance):N/A
- InChl (if other than submission substance):N/A
- Structural formula attached as image file (if other than submission substance): see Fig.N/A
- Substance type: Monoconstituent
- Physical state: Solid, white powder
- Analytical purity: Not reported
- Impurities (identity and concentrations):Not reported
- Composition of test material, percentage of components:Not reported
- Isomers composition:Not reported
- Purity test date:Not reported
- Lot/batch No.: Not reported; received from Great Lakes Chemical Corp.
- Expiration date of the lot/batch: Not reported
- Radiochemical purity (if radiolabelling): N/A
- Specific activity (if radiolabelling): N/A
- Locations of the label (if radiolabelling): N/A
- Expiration date of radiochemical substance (if radiolabelling): N/A
- Stability under test conditions: Not reported
- Storage condition of test material: Not reported
Constituent 1
Test animals
- Species:
- other: 1) Rat; 2) Mouse; 3) Guinea pig
- Strain:
- other: 1) Wistar; 2) NMDI; 3) Not reported
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Not reported (in-house cultures)
- Age at study initiation: Adult?
- Weight at study initiation: Not reported
- Fasting period before study: Not reported
- Housing: Stainless steel inhalation chambers
- Diet (e.g. ad libitum): Standard laboratory diet, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: One week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22C
- Humidity (%): 50-60%
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): Not reported, ambient?
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Stainless steel inhalation chamber
- Exposure chamber volume: Not reported
- Method of holding animals in test chamber: Whole animal placed in chamber
- Source and rate of air: Continuous airflow, flow rate not reported
- Method of conditioning air: Not reported
- System of generating particulates/aerosols: Draeger/Lubeck aerosol apparatus
- Method of particle size determination: Not reported
- Treatment of exhaust air: Not reported
- Temperature, humidity, pressure in air chamber: 22C, 50-50%, Not reported
TEST ATMOSPHERE
- Brief description of analytical method used: No analysis performed
- Samples taken from breathing zone: N/A, no analysis performed
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: No analysis performed
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): No analysis performed - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 24 h
- Concentrations:
- 0.5 mg/l air
- No. of animals per sex per dose:
- Five males and five females per species
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 48 hours
- Frequency of observations and weighing: Not reported
- Necropsy of survivors performed: Yes - Statistics:
- None reported
Results and discussion
- Preliminary study:
- None
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- >= 0.5 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: rat
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- >= 0.5 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: mouse
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- >= 0.5 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: guinea pig
- Mortality:
- None
- Clinical signs:
- other: None
- Body weight:
- Not measured as an endpoint
- Gross pathology:
- No significant findings or pathologic lesions
- Other findings:
- None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- TBBPA was not acutely toxic by inhalation in rats, mice or guinea pigs.
- Executive summary:
Groups of 10 Wistar rats, 10 NMDI-mice, and 10 guinea pigs (five of each sex/group) were exposed for 8 h to a concentration of 0.5 mg TBBPA/L air, and observed for 48 h after exposure. None of the animals showed symptoms of local or systemic toxicity. No gross pathological findings were observed on necropsy. The 8 h LC50 in three mammalian species was >0.5 mg/L air.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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