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EC number: 231-907-1 | CAS number: 7778-53-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Remarks:
- Study was performed prior to the update of the REACH Regulation and prior to the validation of in vitro test methods.
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Code of Federal Regulation, Section 1500.42
- Deviations:
- not specified
- GLP compliance:
- not specified
- Remarks:
- Study pre-dates GLP
Test material
- Reference substance name:
- MCTR-7-75
- IUPAC Name:
- MCTR-7-75
- Test material form:
- other: no data
- Details on test material:
- - Name of test material: MCTR-7-75
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Zartman Farms, Douglassville, Pa.
- Weight at study initiation: 2.0 to 2.5 kg
- Housing: Housed and fed individually
Test system
- Vehicle:
- not specified
- Controls:
- other: The untreated right eye served as a control for each animal.
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- 7 days
- Observation period (in vivo):
- No data
- Number of animals or in vitro replicates:
- 7
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: Not done
SCORING SYSTEM: according to the Federal Register 38 (187) 27019 an animal should be considered as exhibiting a positive reasion if the test stubstace produced at any of the readings, ulceration of the cornea (other than a fine stippling); or opacity of the cornea (other than a slight duling of the normal lustre); or inflammation of the iris (other than a slight deepening of the folds, or rugae, or a slight circumcorneal injection of the blood vessels); or if such substances produce in the conjunctivae (excluding the cornea and iris) an obvious swelling with partial eversion or the lids or a diffuse crimson red with vessles not easily discernible.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- other: all animals tested (#1-6)
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- other: all animals tested (#1-6)
- Time point:
- 24/48/72 h
- Score:
- 2.6
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- iris score
- Basis:
- other: all animals tested (#1-6)
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- cornea opacity score
- Basis:
- other: animal #1, 3, 4 and 6
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 3.6
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 3.33
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritant / corrosive response data:
- All of the test animals exhibited severe irritation at 24, 48 and 72 h. At 4 days, four animals exhibited moderate irritation and two animals exhibited severe irritation. All animals exhibited moderate irritation at 7 days.
- Other effects:
- No data
Any other information on results incl. tables
Eye irritation in rabbits:
Animal No. |
Cornea A x B x 5 |
Iris A x 5 |
Conjunctivae (A + B + C) x 2 |
Total score per animal |
|||
A |
B |
A |
A |
B |
C |
||
24 h |
|||||||
1 |
3 |
4 |
2 |
3 |
3 |
2 |
85 |
2 |
4 |
4 |
2 |
3 |
3 |
2 |
106 |
3 |
3 |
4 |
2 |
3 |
3 |
2 |
86 |
4 |
3 |
4 |
2 |
3 |
3 |
2 |
86 |
5 |
4 |
4 |
2 |
3 |
3 |
2 |
106 |
6 |
3 |
4 |
2 |
3 |
3 |
2 |
86 |
48 h |
|||||||
1 |
3 |
4 |
2 |
3 |
3 |
2 |
86 |
2 |
4 |
4 |
2 |
3 |
3 |
2 |
106 |
3 |
3 |
4 |
2 |
3 |
3 |
2 |
86 |
4 |
3 |
4 |
2 |
3 |
3 |
2 |
86 |
5 |
3 |
4 |
2 |
3 |
3 |
2 |
86 |
6 |
3 |
4 |
2 |
3 |
3 |
2 |
86 |
72 h |
|||||||
1 |
3 |
4 |
2 |
3 |
2 |
3 |
86 |
2 |
3 |
4 |
2 |
3 |
2 |
3 |
86 |
3 |
3 |
4 |
2 |
3 |
2 |
3 |
86 |
4 |
3 |
4 |
2 |
3 |
2 |
3 |
86 |
5 |
3 |
4 |
2 |
3 |
2 |
3 |
86 |
6 |
3 |
4 |
2 |
3 |
2 |
3 |
86 |
4 days |
|||||||
1 |
2 |
4 |
2 |
3 |
2 |
3 |
66 |
2 |
3 |
4 |
2 |
3 |
2 |
3 |
86 |
3 |
2 |
4 |
2 |
3 |
2 |
2 |
64 |
4 |
2 |
4 |
2 |
3 |
2 |
2 |
64 |
5 |
3 |
4 |
2 |
3 |
2 |
2 |
84 |
6 |
2 |
4 |
2 |
2 |
2 |
2 |
62 |
7 days |
|||||||
1 |
2 |
4 |
2 |
2 |
2 |
2 |
62 |
2 |
2 |
4 |
2 |
2 |
2 |
2 |
62 |
3 |
2 |
4 |
2 |
2 |
2 |
2 |
62 |
4 |
2 |
4 |
2 |
2 |
2 |
2 |
62 |
5 |
2 |
4 |
2 |
2 |
2 |
2 |
62 |
6 |
2 |
4 |
2 |
2 |
2 |
2 |
62 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- The test material produced moderate to severe irritation for 7 days when instilled into the eye and not washed out.
The study meets generally accepted scientific standards; however substance identity is not adequately reported (although company records indicate the substance to be tripotassium orthophosphate) and as such this study is not considered to be acceptable for use as a stand-alone source of data but is considered acceptable for use as part of a weight of evidence approach in accordance with Annex XI, section 1.2 of Regulation (EC) No. 1907/2006 (REACH).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.