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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: peer reviewed database

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Acetophenone
Author:
HSDB
Year:
2007
Bibliographic source:
Hazardous Substances Data Bank, printout from 02.08.2007, Last Review Date: Reviewed by SRP on 05/29/2003
Reference Type:
secondary source
Title:
BIBRA working group; TA:Toxicity profile.
Author:
Bibra
Year:
1991
Bibliographic source:
IBRA Toxicology International: 4

Materials and methods

Principles of method if other than guideline:
peer reviewed database, method not reported
GLP compliance:
not specified
Type of study:
other: not specified
Justification for non-LLNA method:
The data was available before the validation of the LLNA method.

Test material

Constituent 1
Chemical structure
Reference substance name:
Acetophenone
EC Number:
202-708-7
EC Name:
Acetophenone
Cas Number:
98-86-2
Molecular formula:
C8H8O
IUPAC Name:
1-phenylethanone

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Results and discussion

In vivo (non-LLNA)

Results
Remarks on result:
no indication of skin sensitisation

Any other information on results incl. tables

/LABORATORY ANIMALS: ... No skin- sensitizing potential was demonstrated. when solutions of acetophenone were tested on guinea-pigs. [BIBRA working group; TA:Toxicity profile. BIBRA Toxicology International: 4 (1991) ]**PEER REVIEWED**

Applicant's summary and conclusion