Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-746-9 | CAS number: 71-23-8
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Human epidermal in vitro permeation test (IVPT) analyses of alcohols and steroids
- Author:
- Azadeh Alinaghi, Ana Macedo, Hanumanth S. Cheruvu, Amy Holmes, Michael S. Roberts
- Year:
- 2 022
- Bibliographic source:
- International Journal of Pharmaceutics 627 (2022) 122114
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 428 (Skin Absorption: In Vitro Method)
- Deviations:
- yes
- Remarks:
- In this work, the study authors explore whether human skin IVPT studies carried out with different receptor conditions and temperatures for a series of aliphatic alcohols and steroids may be made comparable by appropriate adjustment.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Propan-1-ol
- EC Number:
- 200-746-9
- EC Name:
- Propan-1-ol
- Cas Number:
- 71-23-8
- Molecular formula:
- C3H8O
- IUPAC Name:
- propan-1-ol
Constituent 1
- Specific details on test material used for the study:
- Radiolabeled (14C) aliphatic alcohols (ethanol, propanol, pentanol, heptanol and decanol) with ranging activities from 2 to 55 mCi/mmol were purchased from American Radiolabeled Chemicals (St. Louis, MO, USA), diluted in their respective unlabeled alcohol (HPLC grade, Sigma, NSW, Australia) and further diluted in PBS 7.4 (Sigma-Aldrich, NSW, Australia) for use.
- Radiolabelling:
- yes
Results and discussion
Any other information on results incl. tables
Jss (µg.cm− 2.h− 1) 25 ◦C (PBS 7.4) = 1.4 ± 0.6
Jss (µg.cm− 2.h− 1) 25 ◦C (2 %w/v BSA) = 1.4 ± 0.6
kp′ (cm.h− 1) × 10^3 25 ◦C (PBS 7.4) = 2.0 ± 0.9
kp′ (cm.h− 1) × 10^3 25 ◦C (2 %w/v BSA) = 2.0 ± 0.5
Conc. mg/mL = 0.6
Jss = Apparent steady-state flux, kp ′ = apparent permeability coefficient, both presented as mean ± SD for PBS 7.4 (phosphate buffered saline pH 7.4) and 2 %w/v BSA (bovine serum albumin) and Conc. = concentration of the alcohols that permeated through human epidermal membrane over 4–10 h (n = 4–5)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
