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EC number: 273-234-6 | CAS number: 68953-96-8 This substance is identified by SDA Substance Name: C11-C13 branched alkyl benzene sulfonic acid calcium salt and SDA Reporting Number: 25-097-06.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well-documented journal publication.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicologic Studies with Branched and Linear Alkyl Benzene Sulfonates in Rats
- Author:
- Oser, BL, and Morgareidge, K
- Year:
- 1 965
- Bibliographic source:
- Toxicology and Applied Pharmacology 7, 819-25
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Fitzhugh, OG, and Schouboe, PJ. (1959). Subacute toxicity. In: Appraisal of the Safety of Chemicals in Foods, Drugs, and Cosmetics. pp. 26-35. Assoc. of Food and Drug Officials of the US, Bureau of Food and Drugs, Texas State Dept. Of Health, Austi
- GLP compliance:
- no
- Remarks:
- Study was done in 1965 prior to implementation of GLP.
- Limit test:
- no
Test material
- Reference substance name:
- ABS
- IUPAC Name:
- ABS
- Reference substance name:
- LAS
- IUPAC Name:
- LAS
- Details on test material:
- This study compared the toxicity of branched alkyl benzene sulfonates (ABS) to that of linear alkyl benzene sulfonates (LAS).
ABS:
- Physical state: off-white powder
- Impurities (identity and concentrations): petroleum ether-soluble 0.9%, sodium sulfate 10.5%, water 2.2%
- Composition of test material, percentage of components: 87.1% active ABS, average molecular weight 347, average chain length 12
LAS:
- Physical state: yellow viscous liquid
- Impurities (identity and concentrations): free alkali 0.05%, sodium sulfate 8.8%, water 50.9%
- Composition of test material, percentage of components: 39.5% active ABS, average molecular weight 346, average chain length 12
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: albino FDRL
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: weanling
- Housing: individually in wire-mesh cages
- Diet (e.g. ad libitum): ad libitum, Purina Laboratory Chow
- Water (e.g. ad libitum): ad libitum, tap water
Administration / exposure
- Route of administration:
- oral: feed
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 12 weeks
- Frequency of treatment:
- Daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.05, 0.25 g/kg/day
Basis:
nominal in diet
- No. of animals per sex per dose:
- 15 of each sex
- Control animals:
- yes, concurrent no treatment
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: Yes
- Time schedule: Daily
- Cage side observations: appearance, behaviour, and overt signs of toxicity
BODY WEIGHT: Yes
- Time schedule for examinations: weekly
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study): Yes, half of animals of each sex
- Time schedule for examinations: weekly
HAEMATOLOGY: Yes, half of animals of each sex
- Time schedule for collection of blood: weeks 6 and 12
- Parameters checked: hemoglobin, hematocrit, total and differential leucocyte count, blood glucose, and urea nitrogen
URINALYSIS: Yes, half of animals of each sex
- Time schedule for collection of urine: weeks 6 and 12
- Parameters checked: albumin, pH, glucose, microscopic examination of sediment - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes, all animals
liver, kidneys, spleen, heart, adrenals, pituitary, and cecum were weighed
HISTOPATHOLOGY: Yes, 5 rats of each sex in control and high dose groups, all animals of the low dose group though only the liver spleen, stomach, kidneys, and cedum of this group was examined.
liver, spleen, stomach, small intestine, large intestine, pancreas, kidney, bladder, adrenal, gonads, thyroid, pituitary, thymus, salivary gland, lymph node, heart, lung, femoral marrow, aorta, muscle, spinal cord, brain
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Food efficiency:
- no effects observed
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- no effects observed
- Urinalysis findings:
- no effects observed
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- no effects observed
- Details on results:
- CLINICAL SIGNS AND MORTALITY
Occasional signs of wetting in the ventral regions of females in the high dose ABS and high dose LAS groups.
BODY WEIGHT AND WEIGHT GAIN
Body weight gain was normal in all groups.
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study)
Normal in all groups.
FOOD EFFICIENCY
Normal in all groups.
HAEMATOLOGY
Normal in all groups.
CLINICAL CHEMISTRY
Normal in all groups.
URINALYSIS
Normal in all groups.
ORGAN WEIGHTS
Increased liver weights were noted in females in the high dose LAS group, and in both sexes in the high dose ABS group. Increased cecal weights were noted in the high dose male ABS group.
GROSS PATHOLOGY
No treatment related changes noted.
HISTOPATHOLOGY: NON-NEOPLASTIC
No dose related changes noted.
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 50 mg/kg bw/day (nominal)
- Based on:
- act. ingr.
- Sex:
- male/female
- Basis for effect level:
- other: ABS: increased liver weight in both sexes LAS: increased liver weights in females, and increased cecal weights in males
- Dose descriptor:
- LOAEL
- Effect level:
- 250 mg/kg bw/day (nominal)
- Based on:
- act. ingr.
- Sex:
- male/female
- Basis for effect level:
- other: ABS: increased liver weight in both sexes LAS: increased liver weights in females, and increased cecal weights in males
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Body Weight Gain and Organ Weights
|
Control |
0.05 g/kg ABS |
0.25 g/kg ABS |
0.05 g/kg LAS |
0.25 g/kg LAS |
Body Weight Gain |
|
|
|
|
|
Females (g) |
169 |
168 |
152 |
164 |
163 |
Males (g) |
313 |
298 |
315 |
315 |
314 |
Liver Weight |
|
|
|
|
|
Females (%) |
3.86 |
3.98 |
4.67 |
3.77 |
4.34 |
Males (%) |
3.58 |
3.76 |
4.02 |
3.81 |
3.79 |
Cecal Weights |
|
|
|
|
|
Females (%) |
0.58 |
0.64 |
0.65 |
0.57 |
0.58 |
Males (%) |
0.47 |
0.45 |
0.57 |
0.49 |
0.50 |
Applicant's summary and conclusion
- Conclusions:
- The 12-week NOAEL for both ABS and LAS was 50 mg/kg/day. The 12-week LOAEL for both ABS and LAS was 250 mg/kg/day.
- Executive summary:
Groups of 15 male and 15 female rats were fed doses of 0, 50, or 250 mg/kg/day of ABS or LAS in the diet. Exposure lasted 12 weeks. Animals were observed daily for clinical signs. Body weights were taken weekly. Blood and urine analyses were done at week 6 and 12 of exposure. At the end of the exposure period, all animals were sacrificed and gross pathology and histopathology exams performed. Rats of both sexes in the high dose ABS groups showed increased liver weights. Female rats in the high dose LAS group also showed increased liver weights. Males in the high dose LAS group showed increased cecal weights. Based on these endpoints, the 12 week NOAEL for both ABS and LAS was 50 mg/kg/day. The 12 week LOAEL for both ABS and LAS was 250 mg/kg/day.
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