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EC number: 245-018-1 | CAS number: 22464-99-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013-03-20 to 2013-04-04
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- , exclusion of CO2 and O2; two vessels were set up in a parallel design, each vessel was sampled several times instead of sampling one vessel at every point in time.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- , exclusion of CO2 and O2; two vessels were set up in a parallel design, each vessel was sampled several times instead of sampling one vessel at every point in time.
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed, 2011-02-07
- Type of method:
- flask method
- Water solubility:
- < 0.21 µg/L
- Conc. based on:
- element
- Remarks:
- zirconium
- Loading of aqueous phase:
- 50 mg/L
- Incubation duration:
- 3 d
- Temp.:
- 20 °C
- pH:
- >= 4.8 - <= 5.1
- Remarks on result:
- other: dissolved zirconium from day 1 until day 3, at a loading of 50 mg 2-ethylhexanoic acid, zirconium salts/L
- Water solubility:
- < 0.75 µg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 50 mg/L
- Incubation duration:
- 3 d
- Temp.:
- 20 °C
- pH:
- >= 4.8 - <= 5.1
- Remarks on result:
- other: dissolved 2-ethylhexanoic acid, zirconium salts from day 1 until day 3, at a loading of 50 mg/L
- Details on results:
- Observations
During the study, undissolved test material was observed in the media in the flasks. After filtration and subsequent centrifugation, the solutions were clear. In order to verify this, the turbidity was measured in filtered samples.
Temperature
The temperature in the thermostatically controlled water bath was monitored by a Testo 175-T2 thermo datalogger. The mean temperature was 20.5 ± 0.1 °C.
Monitoring oxygen concentration
During the experimental performance of the test, the oxygen concentration in the acrylic glass box was monitored with a MICRO IV oxygen sensor prior and after sampling. The oxygen values remained around 0 %. Slightly negative values, though impossible, are due to measurement uncertainties of the device at 0 % oxygen.
Solution pH
Solution pH in method blanks ranged from 5.4 to 5.9, the pH in samples containing the test item was 4.8 – 5.1. The temperature measured by the pH meter is within 20.0 ± 1.0 °C.
Turbidity
The turbidity was measured after centrifugation and filtration to verify that only dissolved zirconium concentrations would get measured. The turbidity was always <1 NTU, indicating that there was not any undissolved material and micelles did not form after the filtration and centrifugation step.
Dissolved zirconium concentrations
Dissolved zirconium concentrations in method blanks sampled at each time point were below the limit of detection (< 0.30 µg Zr/L) of respective measurement series. Zirconium concentrations in all actual test samples were also below the limit of detection (< 0.21 µg Zr/L) of respective measurement series. - Conclusions:
- Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The water solubility of dissolved 2-ethylhexanoic acid, zirconium salts is < 0.75 µg/L at 20.0 ± 1.0 °C and pH 4.8 – 5.1.
Reference
Method validation summary
validation parameter |
results |
comment |
selectivity |
similar data with at least two different zirconium wavelengths for ICP-OES method |
no matrix effects observed |
linearity |
applied calibration functions were linear |
correlation coefficient at least 0.9991 |
limits of detection |
0.210 – 0.295 µg Zr/L |
|
limits of quantification (LOQ) |
0.629 – 0.884 µg Zr/L |
|
method blanks |
below LOD (< 0.21 µg Zr/L) |
|
accuracy and precision |
mean recovery for Merck Zr standard (10 µg Zr /L): |
for concentration range |
accuracy and precision |
mean recovery for Merck Zr standard (50 µg Zr /L): |
for higher concentration range |
accuracy and precision |
mean recovery for Merck Zr standard (100 µg Zr /L): |
for high concentration range |
accuracy and precision |
recovery from fortification of samples / recalibration samples: 103 – 106 % |
|
repeatability |
mean recovery for Merck Zr standard (10 µg Zr /L): |
for concentration range |
repeatability |
mean recovery for Merck Zr standard (50 µg Zr /L): |
for higher concentration range |
repeatability |
mean recovery for Merck Zr standard (100 µg Zr /L): |
for high concentration range |
Results
During day 1, day 2 and day 3 of testing zirconium concentrations in test samples were always < 0.210 µg/L, i.e. the limit of detection (LOD) of respective ICP-OES measurement series. Therefore, a limit test up to the detection limit of the analytical method is sufficient according to regulation (EC) 1907/2006, Annex VII, point 7.7.
The amount of 2-ethylhexanoic acid, zirconium salt dissolved was calculated based on the zirconium content of the test substance as follows:
= Zr concentration (< 0.21 µg/L) * 100 % / 28 %
mean calculated 2-ethylhexanoic acid, zirconium salt dissolved day 1 – day 3:
< 0.75 µg test item /L
Conclusion
Under the conditions of this test (under exclusion of CO2 and O2, under inert argon gas; flask method; loadings of 50.02 and 50.04 mg/L in vessel 1 and 2, respectively), the amount of dissolved Zr from day 1 until day 3 at 20.0 ± 1.0°C is < 0.21 µg/L (determined as dissolved Zr, separated by filtration). The water solubility of zirconium is below the limit of detection of the respective analytical method (ICP-OES). This corresponds to a calculated water solubility of dissolved 2-ethylhexanoic acid, zirconium salts of < 0.75 µg/L, calculated based on a zirconium content of 28 %. Solution pH in method blanks ranged from 5.4 to 5.9, the pH in samples containing the test item was 4.8 – 5.1.
Description of key information
The water solubility of dissolved 2-ethylhexanoic acid, zirconium salts is < 0.75 µg/L at 20.0 ± 1.0 °C and pH 4.8 – 5.1.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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