Registration Dossier
Registration Dossier
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EC number: 202-196-5 | CAS number: 92-84-2
Bioaccumulation: terrestrial
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No terrestrial bioaccumulation is expected as the log Koc is 3.76. Concomitantly the water solubility as well as the vapour pressure are very low, so no relevant deposition into soil is expected. There are several studies on the metabolism and the toxicokinetics of phenothiazine in mammals and man (e.g. the study cited in section 7.1.1. and Mitchell et. al., Drug Metabolism Reviews, 13(2), 319 -343 (1982)). In this studies it has been shown, that phenothiazine and/or its metabolites are excreted via the urine and faeces, even so, depending on the species, it may take days or week for nearly total elimination. From this studies it can be concluded, that bioaccumulation in terrestrial animals can be considered to be not relevant.
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