Registration Dossier
Registration Dossier
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EC number: 203-881-1 | CAS number: 111-55-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1965
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
- Principles of method if other than guideline:
- Range-finding study, in which 0.01 mL of test material was applied to the intact skin of 5 rabbits.
- GLP compliance:
- no
Test material
- Reference substance name:
- Propane-1,2-diyl diacetate
- EC Number:
- 210-817-6
- EC Name:
- Propane-1,2-diyl diacetate
- Cas Number:
- 623-84-7
- Molecular formula:
- C7H12O4
- IUPAC Name:
- propane-1,2-diyl diacetate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- The nonfasted animals are maintained on appropriate Rockland diets and water ad libitum except during period of manipulation or confinement.
Test system
- Type of coverage:
- open
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.01 mL
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 24 h
- Number of animals:
- 5
- Details on study design:
- The undiluted test substance was applied in 0.01 mL amounts to the clipped intact skin of 5 rabbit bellies.
Results and discussion
In vivo
Results
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- of all 5 animals
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: skin injury, no effect observed at 0.01 mL
- Irritant / corrosive response data:
- No injury from undiluted application was observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: inconclusive
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