Registration Dossier
Registration Dossier
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EC number: 201-280-9 | CAS number: 80-46-6
Endpoint summary
Administrative data
Description of key information
Additional information
Several reliable (Klimisch 1 or 2) toxicity studies in fish, invertebrates, and algae have been conducted for p-tert-amylphenol and are included in this dossier. These Key studies are summarized below. There were no reliable toxicity data for aquatic plants. However, a waiver is being applied for this endpoint.
Adequate reliable measured data exists for short-term toxicity to fish for p-tert-amylphenol and has been documented within this dossier. The most sensitive reliable study result has been identified as a study (Holcombe et al. 1984) which reports an LC50 for short term toxicity in fish of 2.5 mg/L. Consequently this value will be taken as the short-term toxicity in fish endpoint for p-tert-amylphenol.
Reliable (Klimisch 1 or 2) long-term toxicity studies with fish have been conducted for p-tert-amylphenol and are included in this dossier. A study (Seki et al. 2003) provides an estimated NOEC of 0.10 mg/L based on fertility/reproduction. Consequently this value will be taken as the long-term toxicity in fish endpoint for p-tert-amylphenol.
Reliable (Klimisch 1 or 2) short-term toxicity studies with invertebrates have been conducted for p-tert-amylphenol and are included in this dossier. The key study, Davoren and Fogarty (2005,) provides a 48-hr LC50 of 2.7 mg/L for Daphnia magna. Consequently this value will be taken as the short-term toxicity in aquatic invertebrate’s endpoint for p-tert-amylphenol.
There are no reliable (Klimisch 1 or 2) long-term toxicity studies with invertebrates available with the p-tert-amylphenol. However, a reliable (Klimisch 2) long-term toxicity study with invertebrates has been conducted for the analogue, p-tert-butylphenol and is included in this dossier. As provided in the Read Across Report, toxicity data for the analogue substance can be used for toxicity assessment of p-tert-amylphenol. The key study, EA of Japan (1996) provides a NOEC of 0.73 mg/L for Daphnia magna. Consequently this value will be taken as the long-term toxicity in aquatic invertebrate’s endpoint for p-tert-amylphenol.
Adequate reliable measured data exists for toxicity to algae to p-tert-amylphenol. The data point of highest concern for this endpoint has been identified in a reliable study which reports a measured 72 hr EC50 of 4.2 mg/L for toxicity to aquatic algae. Consequently this value will be taken as the toxicity in aquatic algae endpoint for p-tert-amylphenol.
Adequate reliable measured data exists for toxicity to microorganisms to p-tert-amylphenol and has been documented within this dossier. The data point of highest concern for this endpoint has been identified in a reliable study which reports the 24-hr EC50 of 4.5 mg/L. Consequently this value will be taken as the toxicity microorganisms endpoint for p-tert-amylphenol.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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