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Diss Factsheets
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EC number: 931-291-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study meets the EC Standards and is conducted in accordance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Skin corrosivity test described in the US Code of Federal Regulations, title 49, part 173, App. A. Classification system: guidelines of the UN Economic and Social Council (TRANS/GE. 15/R.275, Annex 3, Rev. of Class 8 of RID and ADR, October 1977)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Group of constituents (alkyl derivatives) in Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C7-C17 odd-numbered, C17-unsatd. alkyl) derivs. and sodium hydroxide and chloroacetic acid
- Molecular formula:
- For two representative potential structures: C20H36N2O6Na2 : 446 and C18H35N2O4Na: 367
- IUPAC Name:
- Group of constituents (alkyl derivatives) in Reaction products of 1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-(C7-C17 odd-numbered, C17-unsatd. alkyl) derivs. and sodium hydroxide and chloroacetic acid
- Reference substance name:
- Sodium chloride
- EC Number:
- 231-598-3
- EC Name:
- Sodium chloride
- Cas Number:
- 7647-14-5
- Molecular formula:
- ClNa
- IUPAC Name:
- Sodium chloride
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- Oxidane
- Test material form:
- other: Aqueous solution
- Details on test material:
- - Physical state: Aqueous solution (viscous yellow liquid)
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: A. Smith, 7 Kydcomb Road, Warlingham, Surrey, UK
- Age at study initiation: no data
- Weight at study initiation: 2,3 - 2,8 kg
- Housing: the rabbits were individually housed in grid bottomed metal cages
- Diet (e.g. ad libitum): ad libitum (commercially available pelleted rabbit diet (product ref. 680, Dalgety-Spillers Lmtd))
- Water (e.g. ad libitum): ad libitum (automatic nozzles in each cage)
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18-22
- Humidity (%): 53-65
- Air changes (per hr): no data (air-conditioned)
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: no data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: The dorsal surfaces of the trunk were clipped free of hair using an Oster Model A2 clipper with Angra blade
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: No, comparison with adjacent untreated skin
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 hr
- Observation period:
- 7 days
- Number of animals:
- 6 females
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm x 2.5 cm
- % coverage: no data
- Type of wrap if used: a strip of 5 cm wide plastic adhesive strapping, this acting as an occlusive barrier
After the 4 hour period of exposure, the dressings were removed and the treated areas gently cleaned using cotton wool soaked in water at 37 degrees Celsius.
SCORING SYSTEM: guidelines of the UN Economic and Social Council (TRANS/GE. 15/R.275, Annex 3, Rev. of Class 8 of RID and ADR, October 1977)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- other: mean for animals #1, #2, #3, #4, #5 and #6
- Time point:
- other: Mean value of score at 24, 48 and 72h after patch removal
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- fully reversible within: 168 hrs in all animals
- Remarks on result:
- other: Individual mean scores: 0-0.3-0.7-1.7-0.3-0
- Irritation parameter:
- edema score
- Basis:
- other: mean for animals #1, #2, #3, #4, #5 and #6
- Time point:
- other: Mean value of score at 24, 48 and 72h after patch removal
- Score:
- 0.1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hrs in all animals
- Remarks on result:
- other: Individual mean scores: 0-0-0.3-0-0.3-0
- Other effects:
- None reported
Any other information on results incl. tables
Scores:
Animal No |
Scores |
Mean scores over 24-48-72 hours |
Scores |
|||
1 hour |
24 hours |
48 hours |
72 hours |
|
168 hours |
|
Erythema |
||||||
524 |
0 |
0 |
0 |
0 |
0 |
0 |
525 |
1 |
1 |
0 |
0 |
0.3 |
0 |
526 |
2 |
1 |
1 |
0 |
0.7 |
0 |
530 |
2 |
2 |
2 |
1 |
1.7 |
0 |
531 |
0 |
1 |
0 |
0 |
0.3 |
0 |
534 |
0 |
0 |
0 |
0 |
0 |
0 |
Oedema |
||||||
524 |
0 |
0 |
0 |
0 |
0 |
0 |
525 |
1 |
0 |
0 |
0 |
0 |
0 |
526 |
1 |
1 |
0 |
0 |
0.3 |
0 |
530 |
0 |
0 |
0 |
0 |
0 |
0 |
531 |
2 |
1 |
0 |
0 |
0.3 |
0 |
534 |
0 |
0 |
0 |
0 |
0 |
0 |
REVERSIBILITY:
Effects reversed by day 7 in all 6 animals
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Not irritating
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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