Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 246-356-2 | CAS number: 24613-89-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 February to 17 March 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Proprietary GLP guideline-compliant study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Dichromium tris(chromate)
- EC Number:
- 246-356-2
- EC Name:
- Dichromium tris(chromate)
- Cas Number:
- 24613-89-6
- Molecular formula:
- CrH2O4.2/3Cr
- IUPAC Name:
- dichromium tris(chromate)
- Test material form:
- other: solution
- Details on test material:
- The test material was dichromium tris(chromate) 25% solution, batch no. RCAJ29F1TOX, described as a dark brown liquid. The batch had an expiry date of November 2010, and was stored at room temperature.
All concentrations were expressed as active ingredient.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- The animals were young, healthy adult female CRL:(WI) BR SPF rats obtained from Toxi Coop Ltd (Budapest). The rats were 9-11 weeks old at dosing, weighed 217-234 g, and were nulliparous and non-pregnant. They were acclimatised to the laboratory for at least 22 days. Only healthy (certified by a veterinary surgeon) animals were used for the study.
The rats were housed in groups of 3, in Type II polypropylene/polycarbonate cages with Lignocel Bedding (a copy of the certificate of analysis was retained by the test facility). The temperature in the animal room was 22±3°C, relative humidty was 30-70%, there were 15-20 air changes per hour and light was provided for 12 hours daily.
Animals were fed ssniff SM R/M-Z+H "Autoclavable complete feed for rats and mice - breeding and maintenance" (ssniff Spezialdiaten GmbH, Germany) ad libitum. Tap water from the municipal supply was provided ad libitum.
Individuals were identified by indelible ink markings on the tail.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- distilled
- Details on oral exposure:
- The test substance was administered in a single oral dose by gavage, to rats fasted overnight. Water was not withheld prior to dosing. Animals were weighed immediately prior to treatment. Food was returned 3 hours after dosing.
The dose volume was 10 ml/kg bw. The test item was freshly formulated at a concentration of 0.127 and 0.021 ml/ml in the vehicle on the day of administration. The formulation was stirred continuously during administration, to ensure the syringe was filled from a homogenous liquid.
The test item was expected to have toxic effects (based on Sponsor information), therefore the starting dose chosen was 300 mg/kg of active ingredient.
Initially, three females (group 1) were treated at the 300 mg/kg dose level. Mortality was observed in these animals, so a further three rats (group 2) were treated with 50 mg/kg bw. No mortality occurred in group 2, so a confirmatory group (group 4) were also treated at 50 mg/kg. - Doses:
- 50 and 300 mg/kg bw
- No. of animals per sex per dose:
- 3 females per group
- Control animals:
- no
- Details on study design:
- The rats were observed for 14 days following dosing. Clinical observations were performed on all animals at 30 minutes, 1, 2, 3, 4 and 6 hours after dosing, and daily thereafter. Individual observations were performed and cinluded the skin, fur, eyes, mucous membranes, respiratory, circulatory, autonomic and central nervous system, somatomotor activity and behaviour pattern. Particular attention was given to the observation of tremors, convulsions, saliation, diarrhoea, lethargy, sleep and coma.
Body weights were recorded the day prior to dosing, the day of dosing, and weekly thereafter. All rats were subject to gross necropsy. Surviving animals were saccrificed by exsanguination under pentobarbital anaesthesia. The rats were examined externally, and then the cranial, thoracic and abdominal cavities were opened and the organs and tissues examined macroscopically for abnormalities. - Statistics:
- Not applicable.
Results and discussion
- Preliminary study:
- Not applicable.
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 50 - 300 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- All 3 animals dosed with 300 mg/kg died within 6 hours of dosing.
- Clinical signs:
- other: Decreased activity, hunched posture, dyspnoea, piloerection and soft faeces were observed in all 3 animals administered 300 mg/kg. No adverse effects were noted in the animals dosed with 50 mg/kg.
- Gross pathology:
- Necropsy of the animals dosed with 300 mg/kg revealed dark/brown discolouration of the oesophagus, stomach ad/or digestve content as well as dark/brown discolouration of the lungs associated with yellow liquid in the trachea or nasal cavity. No macropscopic findings were noted in the 500 mg/kg groups.
- Other findings:
- No other findings reported.
Any other information on results incl. tables
No further details.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The acute oral LD50 of dichromium tris(chromate) was between 50 and 300 mg active ingredient/kg bw in female rats.
- Executive summary:
The acute oral toxicity of Dichromium tris(chromate), tested as a water dilution (25% corresponding to 23.6% active ingredient) was evaluated in female CRL:(WI) BR rats, according to the acute toxic class method (OECD 423).
The test substance was administered in a single oral dose by gavage, rats were observed for 14 days post-administration and necropsies were performed on all animals. The first group of 3 females were dosed with 300 mg active ingredient/kg bw. All 3 rats died within 6 hours of dosing, therefore the second group of 3 females were dosed with 50 mg active ingredient/kg bw. No mortalities occurred, so a confirmatory group of 3 females were also dosed with 50 mg active ingredient/kg bw.
Clinical signs observed in all 3 animals administered 300 mg/kg were decreased activity, hunched posture, dyspnoea, piloerection, soft faeces and death. No mortalities occurred in the animals administered 50 mg/kg, and no clinical signs of toxicity were observed in these animals.
Necropsy of the animals dosed with 300 mg/kg revealed dark/brown discolouration of the oesophagus, stomach and/or digestive content, as well as dark/brown discolouration of the lungs associated with yellow liquid in the trachea or nasal cavity. There were no abnormal findings in the 50 mg/kg animals.
The acute oral LD50 of dichromium tris(chromate) was between 50 and 300 mg active ingredient/kg bw in female rats. Based on the results of the study, Dichromium tris(chromate) should be classified as Toxicity Category 3 according to UN GHS and Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.