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EC number: 201-327-3 | CAS number: 81-13-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
The substance was found to be ready biodegradable during testing.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
In a key study, the test item D-Panthenol was investigated for its ready biodegradability in a "28-Day DOC Die-Away Test" according to the Commission Regulation (EC) No 440/2008, C.4-A, the Commission Directive 92/69EEC, C.4-A and the OECD Guideline for Testing of Chemicals, No. 301 A (1992). In accordance with the testing guidelines the test was ended after 21 days since the biodegradation curves of the test and the reference item had reached a plateau over at least three determinations.
In the test flasks, containing the test item D-Panthenol and activated sludge (inoculum), the mean concentrations of dissolved organic carbon (DOC) rapidly decreased by 97% of the initial values within the test period of 21 days. Therefore, D-Panthenol was found to be biodegradable under the test conditions. Moreover, the pass level for ready biodegradability (70 % removal of DOC in a 10-day window within a 28-day period) was reached.
The test item D-Panthenol is therefore readily biodegradable under the test conditions. The reference item sodium benzoate was completely (> 90 %) biodegraded within seven days of exposure, thus confirming suitability of the activated sludge. In the toxicity control, containing the test item, the reference item sodium benzoate and activated sludge (inoculum), the initial DOC decreased by 97% within 14 days of exposure. Thus, according to the test guidelines the test item was not inhibitory to activated sludge at the tested concentration of 54 mg/L because degradation was >35% within 14 days (Harlan, 2011).
In a supporting study evaluating the inherent biodegradability in the Zahns-Wellens/EMPA test according to OECD guideline 302 B, the test substance D-Panthenol had a much shorter adaption-phase as compared to the reference substance diethylene glycol. The degree of biodegradation for D-Panthenol at the end of the test after 15 days was 100 %. The plateau-phase was reached after 12 days. The length of the degradation-phase of the reference substance was in the same range as the one of the test substance.
The physico-chemical degradation of D-Panthenol (without inoculum) was 0 % after 28 days. In the control experiment the reference substance, diethylene glycol, was biodegraded by 100 % after 15 days (DOC comparison). Thus, the used inherent biodegradability test (Zahn-Wellens test) shows evidence for ultimate biodegradation of D-Panthenol (DSM, 1991).
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