Registration Dossier
Registration Dossier
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EC number: 239-622-4 | CAS number: 15571-58-1
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study according Guideline; GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 402
- Deviations:
- yes
- Remarks:
- Additional determination of dermal absorption of the test item (DOTL)
- Principles of method if other than guideline:
- Additional determination of dermal absorption of the test item (DOTL), via Sn in plasma
- GLP compliance:
- yes
Test material
- Reference substance name:
- Dioctyltin dilaurate
- EC Number:
- 222-883-3
- EC Name:
- Dioctyltin dilaurate
- Cas Number:
- 3648-18-8
- Molecular formula:
- C40-H80-O4-Sn
- IUPAC Name:
- dioctyltin dilaurate
- Test material form:
- other: liquid; as such
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24h
- Doses:
- 2000 mg/kg bw
- No. of animals per group:
- 5 female, 5 male
- Control animals:
- no
Results and discussion
- Signs and symptoms of toxicity:
- no effects
- Dermal irritation:
- no effects
Percutaneous absorptionopen allclose all
- Dose:
- 2000 mg/kg
- Parameter:
- percentage
- Absorption:
- 0 %
- Remarks on result:
- other: 3 hours after dosing
- Dose:
- 2000 mg/kg
- Parameter:
- percentage
- Absorption:
- 0 %
- Remarks on result:
- other: 24 hours after dosing
- Conversion factor human vs. animal skin:
- Not relevant, since no absorption was detected
Applicant's summary and conclusion
- Conclusions:
- The study proves, that no Dioctyltin dilaurate has been absorbed via the dermal route.
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