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EC number: 213-635-5 | CAS number: 996-35-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05. Mar 1975 - 02. Apr 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientificially valid study, comparable to guideline, but not according to current standards or GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401.
A test group consisting of 5 animals/sex was treated by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- N,N-dimethylisopropylamine
- EC Number:
- 213-635-5
- EC Name:
- N,N-dimethylisopropylamine
- Cas Number:
- 996-35-0
- Molecular formula:
- C5H13N
- IUPAC Name:
- dimethyl(propan-2-yl)amine
- Details on test material:
- - Name of test material (as cited in study report): N,N-Dimethylisopropylamin
- Analytical purity: 99 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Willi Gassner, Sulzfeld, Germany
- Age at study initiation: about 12 weeks
- Weight at study initiation: 162 - 177 g (average weight)
- Fasting period before study: 16 hours
- Housing: 5 per cage
- Diet: Altromin R 1321; Altromin GmbH, Lage/Lippe, Germany, ad libitum
- Water: Fully demineralized water ad libitum each workday; tap water ad libitum on public holidays.
- Acclimation period: at least 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22-26 °C
- Humidity (%): 45 - 75 %
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 316, 464, 681, 825 and 1000 µl/kg bw corresponding to 228, 334, 490, 594 and 720 mg/kg bw; based on a density of 0.72 g/ml at 20°C.
- No. of animals per sex per dose:
- 5
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Frequency of weighing: days 0, 3, 7, 13
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 684 mg/kg bw
- Mortality:
- 720 mg/kg: 1 male died within 24 h and 3 males within 7 days. 3 femaled died within 48 h.
594 mg/kg: 2 males died within 48 h. - Clinical signs:
- other: 594 mg/kg and 720 mg/kg bw: dyspnoea, staggering, apathy and abdominal position immediately after application. Dyspnoea, apathy, poor general state and aggressiveness during the following observation days. 490 mg/kg bw: staggering, apathy, slightly incr
- Gross pathology:
- 490 mg/kg bw, 594 mg/kg bw and 720 mg/kg bw:
Heart: acute dilation and congestive hyperemia,
Abdominal cavity: adhesion of organs and peritoneum with the stomach, organized perforation of the stomach in one animal at 1000 mg/kg,
Glandular stomach: diffuse red discoloration with hemorrhagic ulcers, corrosive scar in the stomach,
Intestine: reddish content.
Any other information on results incl. tables
Mortality:
Dose (mg/kg ) | Conc. | Gender | 1 h | 24 h | 48 h | day 7 | day 14 | |
720 | 15 | male | 0/5 | 1/5 | 1/5 | 3/5 | 3/5 | |
720 | 15 | female | 0/5 | 2/5 | 3/5 | 3/5 | 3/5 | |
594 | 6 | male | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | |
594 | 6 | female | 0/5 | 2/5 | 2/5 | 2/5 | 2/5 | |
490 | 6 | male | 0/5 | 0/5 | 0/5 | 0/5 | - | |
490 | 6 | female | 0/5 | 0/5 | 0/5 | 0/5 | - | |
334 | 6 | male | 0/5 | 0/5 | 0/5 | 0/5 | - | |
334 | 6 | female | 0/5 | 0/5 | 0/5 | 0/5 | - | |
228 | 3 | male | 0/5 | 0/5 | 0/5 | 0/5 | - | |
228 | 3 | female | 0/5 | 0/5 | 0/5 | 0/5 | - |
Weight (g):
Dose (mg/kg) |
Gender | day 0 | day 3 | day 7 | day 13 | ||
720 | male | 168 | 154 | 204 | 255 | ||
594 | male | 166 | 137 | 176 | 203 | ||
490 | male | 180 | 180 | 196 | - | ||
334 | male | 176 | 219 | 206 | - | ||
228 | male | 195 | 182 | 235 | - | ||
720 | female | 164 | 156 | 147 | 170 | ||
594 | female | 163 | 159 | 169 | 189 | ||
490 | female | 157 | 170 | 157 | - | ||
334 | female | 160 | 177 | 177 | - | ||
228 | female | 164 | 149 | 179 | - |
Harmful if swallowed. There is indication that the test substance causes local irritation to exposed tissue.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The LD50 value was 684 mg/kg bw.
- Executive summary:
The acute oral toxicity of dimethylisopropylamine was evaluated in a study conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401. A test group consisting of 5 animals/sex was treated at dose levels of 228, 334, 490, 594 and 720 mg/kg bw by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy. The LD50 value was 684 mg/kg bw.
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