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EC number: 219-207-4 | CAS number: 2386-87-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 2nd 1992 to August 24th 1992.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Proprietary guideline study.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- Not relevant
- GLP compliance:
- yes
Test material
- Reference substance name:
- 7-oxabicyclo[4.1.0]hept-3-ylmethyl 7-oxabicyclo[4.1.0]heptane-3-carboxylate
- EC Number:
- 219-207-4
- EC Name:
- 7-oxabicyclo[4.1.0]hept-3-ylmethyl 7-oxabicyclo[4.1.0]heptane-3-carboxylate
- Cas Number:
- 2386-87-0
- Molecular formula:
- C14H20O4
- IUPAC Name:
- 7-oxabicyclo[4.1.0]hept-3-ylmethyl 7-oxabicyclo[4.1.0]heptane-3-carboxylate
1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Cyracure UVR-6110
- Substance type: epoxy resin
- Physical state: Colourless, transparent, slightly viscous liquid
- Analytical purity: 100%
- Impurities (identity and concentrations): Not documented
- Composition of test material, percentage of components: 100% 3,4-epoxy cyclohexyl methyl-3,4 epoxy cyclohexyl
carboxylate
- Purity test date: Not documented
- Lot/batch No.: 55-61
- Expiration date of the lot/batch: Not documented
- Stability under test conditions: Not documented
- Storage condition of test material: Stored at room temperature
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Hazleton Research Products, Inc. (Denver, PA).
- Age at study initiation: 12 to 18 weeks of age
- Weight at study initiation: 2.9 - 3.3 kg or 2.6 to 3.5 kg for males and females respectively
- Housing: Housed individually in cages with wire floors (approximately 18 x 24 x 15 in).
- Diet (e.g. ad libitum): AGWAY PROLAB Animal Diet High Fibre Rabbit was available ad libitum except during the actual dosing period.
- Water (e.g. ad libitum): Tap water from the Municipal Authority of Westmoreland County was available ad libitum except during dosing and was supplied by an automatic watering system with demand control valves mounted on each rack.
- Acclimation period: At least 5 days prior to dosing.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16.1 - 21.6°C
- Humidity (%): 40 - 60%
- Air changes (per hr): Not documented
- Photoperiod (hrs dark / hrs light): 12 hour light / dark cycle.
IN-LIFE DATES: From: June 2, 1992 To: June 11, 1992
Test system
- Vehicle:
- not specified
- Controls:
- other: the untreated eye of each animal served as the control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1ml - Duration of treatment / exposure:
- 9 days
- Observation period (in vivo):
- 9 days
(Animals were observed at 1, 24, 48 and 72 hours and at 7 and 9 days following instillation) - Number of animals or in vitro replicates:
- 4 rabbits (2 males and 2 females)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): Not documented
SCORING SYSTEM: Draize (1959) scoring method.
TOOL USED TO ASSESS SCORE: fluorescein staining performed on day 1 and at each subsequent examination days.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other:
- Remarks:
- No effects observed
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other:
- Remarks:
- No effects observed
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- > 0 - <= 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 9 days
- Irritant / corrosive response data:
- A volume of 0.1 ml of test substance instilled into rabbit eyes produced no corneal injury or iritis in any of 4 rabbit eyes dosed. Minor conjunctival irritation was observed in all 4 rabbits within 1 hour. The dosed eye of 1 rabbit healed by 48 hours. The 3 remaining rabbits had a normal ocular appearance within 72 hours to 9 days.
- Other effects:
- No additional effects observed.
Any other information on results incl. tables
No additional information
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Following instillation of 0.1ml of the test substance into the eyes of rabbits, it was determined that CYRACURE UVR-6110 was not irritating to the eyes. Based on these results, the test substance does not require classification according to Regulation EC No. 1272/2008 as it does not meet the criteria for classification outlined. None of the mean scores for corneal iridial or conjunctival reactions exceeded the threshold values requiring classification inaccordance wit Directive 67/548/ EEC, as amended.
- Executive summary:
In a study conducted by Myers et al., (1992),the test substance, CYRACURE UVR-6110 was investigated for its potential to act as an eye irritant. 0.1ml of the test susbtance was placed into the conjunctival sac of one eye of each of 4 animals (2 per sex). The test substance was not removed so the exposure period was 9 days. Following exposure, no corneal injury or iritis in any of 4 rabbit eyes dosed was observed. Minor conjunctival irritation was observed in all 4 animals within one hour, with the dosed eye of 1 rabbit healing by 24 hours and the 3 remaining rabbits had a normal appearance within 72 hours to 9 days. Based on these results, the test substance was considered to be non irritating to eyes. As a result of this, the test substance does not require classification according to Regulation EC No. 1272/2008.
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